Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles (Q41608176)

5 October 2017

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title

Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles (English)

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5 October 2017

P R Cullis

1

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5 October 2017

M J Hope

2

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5 October 2017

M B Bally

3

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5 October 2017

T D Madden

4

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5 October 2017

L D Mayer

5

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5 October 2017

D B Fenske

6

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5 October 2017

language of work or name

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1 September 1997

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5 October 2017

25

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Biochimica et Biophysica Acta

inferred from page(s)

published in

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5 October 2017

1331

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5 October 2017

187-211

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5 October 2017

2

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The measurement of transmembrane electrochemical proton gradients

5 October 2017

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https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

64 The measurement of membrane potential and ΔpH in cells, organelles, and vesicles

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https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

The response of fluorescent amines to pH gradients across liposome membranes.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Measurement of transmembrane potentials in phospholipid vesicles

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https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Estimation of transmembrane potentials from phase equilibriums of hydrophobic paramagnetic ions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Estimation of transmembrane pH gradients from phase equilibriums of spin-labeled amines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Catecholamine uptake and concentration by liposomes maintaining pH gradients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Probing biomembrane interfacial potential and pH profiles with a new type of float-like fluorophores positioned at varying distance from the membrane surface

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Ionization of phospholipids and phospholipid-supported interfacial lateral diffusion of protons in membrane model systems

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

A Rigorous Theory of Remote Loading of Drugs into Liposomes: Transmembrane Potential and Induced pH-Gradient Loading and Leakage of Liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Proton flux in large unilamellar vesicles in response to membrane potentials and pH gradients

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https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Determination of transmembrane pH gradients and membrane potentials in liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Adriamycin cardiomyopathy--risk factors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Characterization of liposomal systems containing doxorubicin entrapped in response to pH gradients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Optimization of the retention properties of vincristine in liposomal systems

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

On the mechanism of transbilayer transport of phosphatidylglycerol in response to transmembrane pH gradients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Transbilayer transport of phosphatidic acid in response to transmembrane pH gradients.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Uptake of basic amino acids and peptides into liposomes in response to transmembrane pH gradients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Influence of charge, charge distribution, and hydrophobicity on the transport of short model peptides into liposomes in response to transmembrane pH gradients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Gelation of liposome interior. A novel method for drug encapsulation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Transmembrane gradient driven phase transitions within vesicles: lessons for drug delivery

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Comparison of free and liposome encapsulated doxorubicin tumor drug uptake and antitumor efficacy in the SC115 murine mammary tumor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Studies on the myelosuppressive activity of doxorubicin entrapped in liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Liposomes with entrapped doxorubicin exhibit extended blood residence times

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Chromatographic analysis and pharmacokinetics of liposome-encapsulated doxorubicin in non-small-cell lung cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Recent advances in liposomal drug-delivery systems

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Liposomal-entrapped doxorubicin: an active agent in AIDS-related Kaposi's sarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Sphingomyelin-cholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Modulation of membrane fusion by asymmetric transbilayer distributions of amino lipids

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Intervesicular exchange of lipids with weak acid and weak base characteristics: influence of transmembrane pH gradients.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Phospholipid asymmetry in large unilamellar vesicles induced by transmembrane pH gradients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

1 reference

7 January 2021

Energetics of intermediates in membrane fusion: comparison of stalk and inverted micellar intermediate mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Ca2+ and pH induced fusion of small unilamellar vesicles consisting of phosphatidylethanolamine and negatively charged phospholipids: a freeze fracture study.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Effect of transbilayer phospholipid distribution on erythrocyte fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Differentiation-related differences in the plasma membrane phospholipid asymmetry of myogenic and fibrogenic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

The cesium-induced delay in myoblast membrane fusion is accompanied by changes in isolated membrane lipids

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Ca(2+)-induced fusion of phospholipid vesicles containing free fatty acids: modulation by transmembrane pH gradients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Influence of phospholipid asymmetry on fusion between large unilamellar vesicles.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Modification by diacylglycerol of the structure and interaction of various phospholipid bilayer membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Shape transitions and shape stability of giant phospholipid vesicles in pure water induced by area-to-volume changes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Shape changes of giant liposomes induced by an asymmetric transmembrane distribution of phospholipids

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Influence of transbilayer area asymmetry on the morphology of large unilamellar vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

A novel method for the efficient entrapment of calcium in large unilamellar phospholipid vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Generation and characterization of iron- and barium-loaded liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Ionophore-mediated loading of Ca2+ into large unilamellar vesicles in response to transmembrane pH gradients.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Fluorescence study of the divalent cation-transport mechanism of ionophore A23187 in phospholipid membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Movement of calcium through artificial lipid membranes and the effects of ionophores

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Lanthanide-ion transport across phospholipid vesicular membranes: a comparison of alamethicin 30 and A23187 using 1H-NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

The stoichiometry of A23187- and X537A-mediated calcium ion transport across lipid bilayers

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Paramagnetic agents for contrast-enhanced NMR imaging: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

The design of liposomal paramagnetic MR agents: effect of vesicle size upon the relaxivity of surface-incorporated lipophilic chelates

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

In-111-labeled liposomes: dosimetry and tumor depiction

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Active proton uptake by chromaffin granules: observation by amine distribution and phosphorus-31 nuclear magnetic resonance techniques

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Phosphorus-31 nuclear magnetic resonance studies of active proton translocation in chromaffin granules

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Dopamine accumulation in large unilamellar vesicle systems induced by transmembrane ion gradients.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Catecholamine transport through a lipid barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Dissociation constants and lipophilicity of catecholamines and related compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Energy-dependent accumulation of neuron blockers causes selective inhibition of neurotransmitter uptake by brain synaptic vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Intracellular pH and the control of multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

The biochemistry of P-glycoprotein-mediated multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Is the multidrug transporter a flippase?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

ATP-binding properties of P glycoprotein from multidrug-resistant KB cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Proton-translocating adenosine triphosphatase in rough and smooth microsomes from rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Characterization of MgATP-driven H+ uptake into a microsomal vesicle fraction from rat pancreatic acinar cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

The effect of intracellular pH on long-chain fatty acid uptake in 3T3-L1 adipocytes: evidence that uptake involves the passive diffusion of protonated long-chain fatty acids across the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Lipid Asymmetry in Membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Static and dynamic lipid asymmetry in cell membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Transbilayer movement of phospholipids in red cell and platelet membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Protein transport across the ER membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Function of protonmotive force in translocation of protein across membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

A new type of signal peptide: central role of a twin-arginine motif in transfer signals for the delta pH-dependent thylakoidal protein translocase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

The delta pH-driven, ATP-independent protein translocation mechanism in the chloroplast thylakoid membrane. Kinetics and energetics

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Sec-dependent thylakoid protein translocation. Delta pH requirement is dictated by passenger protein and ATP concentration

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Common principles of protein translocation across membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

Approaching the mechanism of protein transport across the ER membrane.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2897%2900006-3

7 January 2021

10.1016/S0304-4157(97)00006-3

Identifiers

DOI

1 reference

5 October 2017

1 reference