Enzymatic glycosylation of nonbenzoquinone geldanamycin analogs via Bacillus UDP-glycosyltransferase. (Q41592955)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22923401%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Enzymatic glycosylation of nonbenzoquinone geldanamycin analogs via Bacillus UDP-glycosyltransferase (English)

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12 February 2020

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6

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12 February 2020

author name string

Cheng-Zhu Wu

1

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12 February 2020

Jae-Hyuk Jang

2

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12 February 2020

Mihee Woo

3

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12 February 2020

Jong Seog Ahn

4

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12 February 2020

Joong Su Kim

5

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12 February 2020

language of work or name

English

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publication date

24 August 2012

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Applied and Environmental Microbiology

12 February 2020

published in

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12 February 2020

volume

78

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12 February 2020

issue

21

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12 February 2020

page(s)

7680-7686

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Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules

12 February 2020

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New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus.

6 June 2018

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6-Alkylsalicylic acid analogues inhibit in vitro ATPase activity of heat shock protein 90.

6 June 2018

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Recombinant E. coli prototype strains for in vivo glycorandomization.

6 June 2018

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Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

6 June 2018

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A bacterial glycosyltransferase gene toolbox: generation and applications

6 June 2018

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Rational biosynthetic engineering for optimization of geldanamycin analogues

6 June 2018

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A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

6 June 2018

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Glycosyltransferases, important tools for drug design

6 June 2018

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Molecular characterization of macbecin as an Hsp90 inhibitor

6 June 2018

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Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution

6 June 2018

1 reference

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Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates

6 June 2018

1 reference

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Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

6 June 2018

1 reference

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'Sweetening' natural products via glycorandomization

6 June 2018

1 reference

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Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption

6 June 2018

1 reference

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Synthesis and enzyme-specific activation of carbohydrate-geldanamycin conjugates with potent anticancer activity.

6 June 2018

1 reference

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Antibiotic optimization via in vitro glycorandomization

6 June 2018

1 reference

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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

6 June 2018

1 reference

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A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

6 June 2018

1 reference

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The role of carbohydrates in biologically active natural products

6 June 2018

1 reference

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

6 June 2018

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Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

6 June 2018

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Formation of flavone di-O-glucosides using a glycosyltransferase from Bacillus cereus.

6 June 2018

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Chapter 12. The power of glycosyltransferases to generate bioactive natural compounds

19 August 2018

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Engineering a function into a glycosyltransferase

19 August 2018

1 reference

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Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

19 August 2018

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Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring.

19 August 2018

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Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin.

19 August 2018

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Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

19 August 2018

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Geldanamycin, a new antibiotic

19 August 2018

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Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22923401

12 December 2020

inferred from PubMed ID database lookup

Reaction of geldanamycin and C17-substituted analogues with glutathione: product identifications and pharmacological implications

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22923401

12 December 2020

inferred from PubMed ID database lookup

The missing C-17 O-methyltransferase in geldanamycin biosynthesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22923401

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1128/AEM.02004-12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22923401%20AND%20SRC:MED&resulttype=core&format=json

release_aismmg2orzbyxbsxrnotdolrkq

12 February 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/aismmg2orzbyxbsxrnotdolrkq

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22923401%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference