Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding. (Q41508882)

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scientific article published on 2 July 2012

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English	Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding.	scientific article published on 2 July 2012

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6 February 2020

Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding (English)

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6 February 2020

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6 February 2020

author name string

Rubén Martín

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Claudia Cordova

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2 July 2012

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Journal of Neuroinflammation

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https://scigraph.springernature.com/pub.10.1186/1742-2094-9-154

0 references

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia.

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Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-1alpha/beta after transient focal cerebral ischemia in rat.

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Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease

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Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury

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10 June 2018

Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly

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Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective.

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10 June 2018

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Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding

1 reference

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12 December 2020

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Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR

1 reference

https://pubmed.ncbi.nlm.nih.gov/22747893

12 December 2020

based on heuristic

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1 reference

https://pubmed.ncbi.nlm.nih.gov/22747893

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22747893

12 December 2020

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Preparation of a monoclonal antibody to a glycidic epitope of the epidermal growth factor receptor that recognizes inhibitors of astrocyte proliferation and reactive microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22747893

12 December 2020

based on heuristic

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Identifiers

10.1186/1742-2094-9-154

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6 February 2020

Dimensions Publication ID

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9 September 2019

https://scigraph.springernature.com/pub.10.1186/1742-2094-9-154

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Europe PubMed Central

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6 February 2020

1 reference

Europe PubMed Central

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6 February 2020

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