Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (Q41445253)

30 September 2017

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title

Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (English)

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30 September 2017

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J P Desager

1

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PubMed ID

9118584

30 September 2017

Y Horsmans

series ordinal

2

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30 September 2017

1 November 1996

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Clinical Pharmacokinetics

30 September 2017

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30 September 2017

31

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30 September 2017

348-371

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30 September 2017

5

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https://scigraph.springernature.com/pub.10.2165/00003088-199631050-00003

30 September 2017

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12 December 2020

A two component-type cytochrome P-450 monooxygenase system in a prokaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

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Pharmacokinetics and pharmacodynamics of pravastatin alone and with cholestyramine in hypercholesterolemia

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Regulation of the mevalonate pathway

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Management of primary hyperlipidemia

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Interaction between fibre and lovastatin

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12 December 2020

In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes

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12 December 2020

Decreased in vitro oxidizability of low-density lipoprotein in hypercholesterolaemic patients treated with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors

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12 December 2020

Regulation of bile acid synthesis in humans: effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7 alpha-hydroxylation rates in vivo

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The effect of zileuton on antipyrine and indocyanine green disposition

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12 December 2020

Effects of fluvastatin (XU 62-320), an HMG-CoA reductase inhibitor, on the distribution and composition of low density lipoprotein subspecies in humans

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12 December 2020

Influence of age and gender on the plasma profiles of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitory activity following multiple doses of lovastatin and simvastatin

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12 December 2020

Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects.

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12 December 2020

Determination of pravastatin sodium and its major metabolites in human serum/plasma by capillary gas chromatography/negative ion chemical ionization mass spectrometry

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12 December 2020

Regulation of cholesteryl ester transfer protein (CETP) activity: review of in vitro and in vivo studies

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12 December 2020

Biotransformation of lovastatin. IV. Identification of cytochrome P450 3A proteins as the major enzymes responsible for the oxidative metabolism of lovastatin in rat and human liver microsomes

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12 December 2020

Short- and long-term effects of lovastatin and pravastatin alone and in combination with cholestyramine on serum lipids, lipoproteins and apolipoproteins in primary hypercholesterolaemia

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12 December 2020

Evaluation of sustained/controlled-release dosage forms of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors in dogs and humans

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12 December 2020

Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo

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12 December 2020

Effect of food on pravastatin pharmacokinetics and pharmacodynamics

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12 December 2020

Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin

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12 December 2020

Effects of pravastatin (CS-514) on biliary lipid metabolism in patients with hyperlipidemia

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12 December 2020

Effects of simvastatin and pravastatin on 6 beta-hydroxycortisol excretion, a potential marker of cytochrome P-450 3A

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12 December 2020

Fat transport in lipoproteins--an integrated approach to mechanisms and disorders

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12 December 2020

Effects of MK-733 (simvastatin), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on intestinal acylcoenzyme A:cholesterol acyltransferase activity in rabbits

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12 December 2020

Clinical pharmacokinetics and practical applications of simvastatin

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12 December 2020

Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers

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12 December 2020

Pravastatin has no direct effect on transmembrane cationic transport systems in human erythrocytes and platelets

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12 December 2020

Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

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12 December 2020

Lack of effect of lovastatin therapy on the parameters of whole-body cholesterol metabolism

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12 December 2020

Metabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects

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12 December 2020

Biotransformation of lovastatin--III. Effect of cimetidine and famotidine on in vitro metabolism of lovastatin by rat and human liver microsomes

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12 December 2020

Lathosterol and other noncholesterol sterols during treatment of hypercholesterolemia with lovastatin alone and with cholestyramine or guar gum

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12 December 2020

Comparative effects of simvastatin (MK-733) and pravastatin (CS-514) on hypercholesterolemia induced by cholesterol feeding in rabbits

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12 December 2020

Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia

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12 December 2020

Lovastatin decreases coenzyme Q levels in humans

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12 December 2020

Modulation of chylomicron remnant metabolism by an hepatic hydroxymethylglutaryl coenzyme A reductase inhibitor

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12 December 2020

Pravastatin therapy in primary moderate hypercholesterolaemia: changes in metabolism of apolipoprotein B-containing lipoproteins

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12 December 2020

Comparative pharmacokinetics and pharmacodynamics of pravastatin and lovastatin.

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12 December 2020

Effects of pravastatin and ursodeoxycholic acid on cholesterol and bile acid metabolism in patients with cholesterol gallstones.

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12 December 2020

Plasma concentration profiles of simvastatin 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitory activity in kidney transplant recipients with and without ciclosporin

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12 December 2020

Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia.

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12 December 2020

The discovery and development of HMG-CoA reductase inhibitors

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12 December 2020

Effect of a long-term treatment with lovastatin or fenofibrate on hepatic and cardiac ubiquinone levels in cardiomyopathic hamster

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12 December 2020

Effects of simvastatin on plasma lipoprotein subfractions, cholesterol esterification rate, and cholesteryl ester transfer protein in type II hyperlipoproteinemia

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12 December 2020

Effects of lovastatin on biliary lipid secretion and bile acid metabolism in humans

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12 December 2020

Effect of lovastatin on cholesterol content of cardiac and red blood cell membranes in normal and cardiomyopathic hamsters

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12 December 2020

Disposition of pravastatin sodium, a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects

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12 December 2020

Biotransformation of fluvastatin sodium in humans

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12 December 2020

Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol.

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12 December 2020

Changes in Lp(a) lipoprotein levels during the treatment of hypercholesterolaemia with simvastatin

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12 December 2020

Simultaneous determination of simvastatin and its hydroxy acid form in human plasma by high-performance liquid chromatography with UV detection

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12 December 2020

The seven countries study: 2,289 deaths in 15 years

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12 December 2020

Physiological disposition of HMG-CoA-reductase inhibitors

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12 December 2020

Activity of low-density lipoprotein receptors as estimated from concentrations of apolipoprotein B and C-II in serum

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12 December 2020

Effect of apolipoprotein E and A-IV phenotypes on the low density lipoprotein response to HMG CoA reductase inhibitor therapy

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12 December 2020

Lp(a) lipoprotein: an overview

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12 December 2020

Pharmacokinetics of fluvastatin after single and multiple doses in normal volunteers

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12 December 2020

Tissue-selective action of pravastatin due to hepatocellular uptake via a sodium-independent bile acid transporter.

1 reference

12 December 2020

Purification and characterization of cytochrome P-450sca from Streptomyces carbophilus. ML-236B (compactin) induces a cytochrome P-450sca in Streptomyces carbophilus that hydroxylates ML-236B to pravastatin sodium (CS-514), a tissue-selective inhibi

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12 December 2020

High-performance liquid chromatographic method for the determination of fluvastatin in human plasma

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12 December 2020

Effects of combined bezafibrate-simvastatin appraised in healthy subjects

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12 December 2020

Serum lipoprotein Lp(a) concentrations are not influenced by an HMG CoA reductase inhibitor

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12 December 2020

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

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12 December 2020

Central nervous system effects of HMG CoA reductase inhibitors: lovastatin and pravastatin on sleep and cognitive performance in patients with hypercholesterolemia.

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12 December 2020

Influence of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Pravastatin, on Corticosteroid Metabolism in Patients with Heterozygous Familial Hypercholesterolemia

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12 December 2020

Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

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12 December 2020

Lecithin: cholesterol acyltransferase activity in familial hypercholesterolemia treated with simvastatin and simvastatin plus low-dose colestipol

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12 December 2020

Effects of simvastatin on apoB metabolism and LDL subfraction distribution

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12 December 2020

Fluvastatin: a review of its pharmacology and use in the management of hypercholesterolaemia

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12 December 2020

Clinical implications of the biopharmaceutical properties of fluvastatin.

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12 December 2020

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase

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12 December 2020

Secondary causes of hyperlipidemia.

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12 December 2020

Altered disposition of pravastatin following concomitant drug therapy with cyclosporin A in transplant recipients

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12 December 2020

Effects of MK-733, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on absorption and excretion of [3H]cholesterol in rabbits

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12 December 2020

Determination of pravastatin sodium and its isomeric metabolite in human urine by HPLC with UV detection

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12 December 2020

Pharmacokinetics of fluvastatin and specific drug interactions

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12 December 2020

Effects of alcohol and fluvastatin on lipid metabolism and hepatic function

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12 December 2020

Effects of lovastatin therapy on very-low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: evidence for reduced assembly and secretion of triglyceride-rich lipoproteins

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12 December 2020

Factors of risk in the development of coronary heart disease--six year follow-up experience. The Framingham Study

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12 December 2020

The physiological disposition of lovastatin

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12 December 2020

Plasma cholesteryl ester transfer protein

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12 December 2020

Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages

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12 December 2020

Serum Lp(a) concentrations are unaffected by treatment with the HMG-CoA reductase inhibitor Pravastatin: results of a 2-year investigation

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12 December 2020

Influence of cholesterol lowering on plasma membrane lipids and cationic transport systems

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12 December 2020

National Cholesterol Education Program. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

1 reference

12 December 2020

Inhibition of acyl coenzyme A: cholesterol acyltransferase by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

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12 December 2020

Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor

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12 December 2020

Effect of lovastatin on cholesterol absorption in cholesterol-fed rabbits

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12 December 2020

Highly sensitive and specific determination of pravastatin sodium in plasma by high-performance liquid chromatography with laser-induced fluorescence detection after immobilized antibody extraction

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12 December 2020

Single-Dose Pharmacokinetics of Pravastatin and Metabolites in Patients with Renal Impairment

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12 December 2020

Apoliproproteins and lipoproteins

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12 December 2020

Effect of simvastatin on receptor-dependent low density lipoprotein catabolism in normocholesterolemic human volunteers

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12 December 2020

Single-dose pharmacokinetics of 14C-lovastatin in chronic renal failure.

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12 December 2020

Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug

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12 December 2020

Metabolic disposition of simvastatin in patients with T-tube drainage.

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12 December 2020

Lovastatin. A preliminary review of its pharmacodynamic properties and therapeutic use in hyperlipidaemia

1 reference

12 December 2020

Simvastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia

1 reference

12 December 2020

Regulation of cholesterol synthesis: mechanism for control of HMG CoA reductase

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12 December 2020

Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

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12 December 2020

Plasma high density lipoprotein particle size alteration by simvastatin treatment in patients with hypercholesterolaemia.

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12 December 2020

Effect of fluvastatin on plasma apolipoprotein-B-containing particles, including lipoprotein(a). European Fluvastatin Study Group

1 reference

12 December 2020

Effects of pravastatin on apolipoprotein-specific high density lipoprotein subpopulations and low density lipoprotein subclass phenotypes in patients with primary hypercholesterolemia

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12 December 2020

Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy

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12 December 2020

Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits

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12 December 2020

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin

1 reference

12 December 2020

New approaches to atherosclerosis: an overview

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12 December 2020

A comparison of the effects of simvastatin and pravastatin monotherapy on muscle histology and permeability in hypercholesterolaemic patients

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12 December 2020

A review of clinical trials comparing HMG-CoA reductase inhibitors

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12 December 2020

Lovastatin decreases plasma and platelet cholesterol levels and normalizes elevated platelet fluidity and aggregation in hypercholesterolemic patients

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12 December 2020

Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase

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12 December 2020

Simvastatin-induced decrease in the transfer of cholesterol esters from high density lipoproteins to very low and low density lipoproteins in normolipidemic subjects

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12 December 2020

Pravastatin modulates cholesteryl ester transfer from HDL to apoB-containing lipoproteins and lipoprotein subspecies profile in familial hypercholesterolemia

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12 December 2020

The plasma lecithins:cholesterol acyltransferase reaction

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12 December 2020

Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans

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12 December 2020

Pharmacokinetic interaction between propranolol and the HMG-CoA reductase inhibitors pravastatin and lovastatin

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12 December 2020

Enhanced cellular metabolism of very low density lipoprotein by simvastatin. A novel mechanism of action of HMG-CoA reductase inhibitors

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12 December 2020

Effect of simvastatin on high density lipoprotein subfractions and apolipoproteins in type IIa hypercholesterolemia.

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12 December 2020

Acquired hyperlipidemia (secondary dyslipoproteinemias).

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12 December 2020

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

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12 December 2020

Pravastatin lowers serum cholesterol, cholesterol-precursor sterols, fecal steroids, and cholesterol absorption in man

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12 December 2020

The interaction of cholesterol absorption and cholesterol synthesis in man

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12 December 2020

Independent associations between plasma lipoprotein subfraction levels and the course of coronary artery disease in the St. Thomas' Atherosclerosis Regression Study (STARS)

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12 December 2020

Simvastatin (MK 733) in heterozygous familial hypercholesterolemia: a two-year trial

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12 December 2020

Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation

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12 December 2020

Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme A reductase inhibitors

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12 December 2020

Pharmacology of competitive inhibitors of HMG-CoA reductase.

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12 December 2020

Effects of simvastatin, a lipoprotein-lowering drug, on the hepatic enzymes involved in drug metabolism in the Wistar rat

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12 December 2020

The hypolipidemic effects of lovastatin and clofibrate alone and in combination in patients with type III hyperlipoproteinemia

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12 December 2020

Molecular physiology of reverse cholesterol transport

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12 December 2020

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

1 reference

12 December 2020

The interaction of fluvastatin and cyclosporin A in renal transplant patients

1 reference

12 December 2020

Gastrointestinal absorption of pravastatin in healthy subjects

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12 December 2020

Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin (HMG CoA reductase-inhibitor).

1 reference

12 December 2020

Pravastatin effectively lowers LDL cholesterol in familial combined hyperlipidemia without changing LDL subclass pattern

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12 December 2020

In vivo inhibition profile of cytochrome P450TB (CYP2C9) by (+/-)-fluvastatin

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12 December 2020

Comparison of the efficacy, safety and tolerability of simvastatin and pravastatin for hypercholesterolemia. The Simvastatin Pravastatin Study Group

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12 December 2020

Primary prevention of atherosclerosis by lovastatin in a genetically hyperlipidaemic rabbit strain

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12 December 2020

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

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12 December 2020

10.2165/00003088-199631050-00003

Identifiers

DOI

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PubMed ID

9118584

Dimensions Publication ID

30 September 2017

0 references

1 reference

PubMed ID

9118584