Substrate path in the AcrB multidrug efflux pump of Escherichia coli. (Q41406243)

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13 February 2020

title

Substrate path in the AcrB multidrug efflux pump of Escherichia coli (English)

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13 February 2020

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1

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13 February 2020

author name string

Hiroshi Nikaido

series ordinal

2

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language of work or name

English

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publication date

20 August 2010

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13 February 2020

published in

Molecular Microbiology

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volume

78

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issue

2

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page(s)

320-330

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describes a project that uses

13 February 2020

ImageJ

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

cites work

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

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1 October 2017

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Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism

1 October 2017

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The structure of the efflux pump AcrB in complex with bile acid

1 October 2017

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Site-directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB.

1 October 2017

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Drug-induced conformational changes in multidrug efflux transporter AcrB from Haemophilus influenzae

1 October 2017

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Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

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Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway

1 October 2017

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Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network

1 October 2017

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Mutations in the central cavity and periplasmic domain affect efflux activity of the resistance-nodulation-division pump EmhB from Pseudomonas fluorescens cLP6a

1 October 2017

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A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.

1 October 2017

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Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps

1 October 2017

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Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein

1 October 2017

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Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa

1 October 2017

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Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump

1 October 2017

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Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops

1 October 2017

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Crystal structure of bacterial multidrug efflux transporter AcrB

1 October 2017

1 reference

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Mystery of multidrug transporters: the answer can be simple

1 October 2017

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Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy

1 October 2017

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Entry into and release of solvents by Escherichia coli in an organic-aqueous two-liquid-phase system and substrate specificity of the AcrAB-TolC solvent-extruding pump

1 October 2017

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Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

1 October 2017

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1 October 2017

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Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli

1 October 2017

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1 October 2017

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1 October 2017

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Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates

1 October 2017

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11 June 2018

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AcrA is a highly asymmetric protein capable of spanning the periplasm

11 June 2018

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11 June 2018

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11 June 2018

1 reference

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Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance

11 June 2018

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Site-directed disulfide cross-linking shows that cleft flexibility in the periplasmic domain is needed for the multidrug efflux pump AcrB of Escherichia coli

19 August 2018

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Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF).

19 August 2018

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Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.

19 August 2018

1 reference

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Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3008161

The role of outer membrane and efflux pumps in the resistance of gram-negative bacteria. Can we improve drug access?

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3008161

AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3008161

Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3008161

On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3008161

10.1111/J.1365-2958.2010.07330.X

19 August 2018

Identifiers

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13 February 2020

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13 February 2020

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