The metabolism of psychoactive drugs: a review of enzymatic biotransformation and inhibition (Q41401684)

30 September 2017

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title

The metabolism of psychoactive drugs: a review of enzymatic biotransformation and inhibition (English)

1 reference

30 September 2017

W W Shen

1

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PubMed ID

9084901

30 September 2017

language of work or name

English

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publication date

1 April 1997

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30 September 2017

Biological Psychiatry

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30 September 2017

41

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30 September 2017

7

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30 September 2017

814-826

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Clozapine--pharmacokinetic investigations and biochemical effects in man.

30 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Ethanol-induced enhancement of cocaine bioactivation and irreversible protein binding: evidence against a role of cytochrome P-450IIE1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Plasma levels of perphenazine and its major metabolites during simultaneous treatment with anticholinergic drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

7 January 2021

1 reference

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Valproate plasma protein binding in the uremic condition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Review of the animal pharmacology and pharmacokinetics of fluvoxamine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Carbamazepine metabolism in man. Induction and pharmacogenetic aspects

7 January 2021

1 reference

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Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia

7 January 2021

1 reference

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Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study*

7 January 2021

1 reference

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Lorazepam kinetics in the elderly

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Metabolic pathway of paroxetine in animals and man and the comparative pharmacological properties of its metabolites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Selective inhibitors of cytochromes P450.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

The effect of dietary energy and protein deficiency on drug metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Distinct induction profiles of three phenobarbital-responsive mouse liver cytochrome P450 isozymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Drug interaction effects on antitumour drugs (XV): Disulfiram as protective agent against cyclophosphamide-induced urotoxicity without compromising antitumour activity in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Fluvoxamine Inhibition and Carbamazepine Induction of the Metabolism of Clozapine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Cocaine-induced liver cell injury: comparison of morphological features in man and in experimental models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Inhibition of human liver microsomal epoxide hydrolase by valproate and valpromide: in vitro/in vivo correlation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Clinical enflurane metabolism by cytochrome P450 2E1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Human N-acetylation genotype determination with urinary caffeine metabolites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Introduction of a composite parameter to the pharmacokinetics of venlafaxine and its active O-desmethyl metabolite

7 January 2021

1 reference

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Differential inhibition of individual human liver cytochromes P-450 by cimetidine

7 January 2021

1 reference

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The effects of selective serotonin reuptake inhibitors and their metabolites on S-mephenytoin 4'-hydroxylase activity in human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes

7 January 2021

1 reference

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A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

7 January 2021

1 reference

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Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors

7 January 2021

1 reference

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Mephenytoin hydroxylation deficiency: kinetics after repeated doses

7 January 2021

1 reference

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Purification and characterization of human liver cytochrome P-450-ALC

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

The effect of fluoxetine on the pharmacokinetics and psychomotor responses of diazepam.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding

7 January 2021

1 reference

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An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Clinical pharmacokinetics of tacrine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers

7 January 2021

1 reference

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Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

7 January 2021

1 reference

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Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative

7 January 2021

1 reference

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Molecular mechanisms of the hepatotoxicity caused by acetaminophen

7 January 2021

1 reference

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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

7 January 2021

1 reference

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Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline

7 January 2021

1 reference

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The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders. A Nordic multicentre study.

7 January 2021

1 reference

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Effects of tetrahydroaminoacridine on liver function in patients with Alzheimer's disease

7 January 2021

1 reference

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A potentially hazardous interaction between erythromycin and midazolam.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects.

7 January 2021

1 reference

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Recent developments in drug metabolism of relevance to psychiatrists

7 January 2021

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Triazolam in cirrhosis: pharmacokinetics and pharmacodynamics

7 January 2021

1 reference

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Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

d-Propoxyphene is a potent inhibitor of debrisoquine, but not S-mephenytoin 4-hydroxylation in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Cytochrome P450 monooxygenases and interactions of psychotropic drugs: a five-year update

7 January 2021

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Cytochrome P-450 monooxygenases and interactions of psychotropic drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: Nonlinearity and relation to the sparteine oxidation polymorphism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

The relationship between paroxetine and the sparteine oxidation polymorphism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Interaction between fluvoxamine and imipramine/desipramine in four patients

7 January 2021

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Possible inhibition of hepatic metabolism of quinidine by erythromycin

7 January 2021

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Delirium induced by the competitive interaction between phenytoin and dipropylacetate.

7 January 2021

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Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase).

7 January 2021

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Inhibitors of P450-dependent steroid biosynthesis: from research to medical treatment.

7 January 2021

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Is there a case for P-450 inhibitors in cancer treatment?

7 January 2021

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Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

7 January 2021

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Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism

7 January 2021

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Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients.

7 January 2021

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Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation

7 January 2021

1 reference

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Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2896%2900180-1

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1016/S0006-3223(96)00180-1

1 reference

30 September 2017

1 reference

PubMed ID

9084901