Adipogenesis and obesity: rounding out the big picture (Q41193513)

28 September 2017

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title

Adipogenesis and obesity: rounding out the big picture (English)

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28 September 2017

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2

Flier JS

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28 September 2017

Spiegelman BM

1

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PubMed ID

8898192

28 September 2017

language of work or name

English

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publication date

1 November 1996

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28 September 2017

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28 September 2017

87

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28 September 2017

377-389

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28 September 2017

3

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Comparison of body composition, adipocyte size, and glucose and insulin concentrations in Pima Indian and Caucasian children

28 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Role of leptin in the neuroendocrine response to fasting

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Leptin enters the brain by a saturable system independent of insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Differential activation of adipogenesis by multiple PPAR isoforms.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Molecular characterization of the mouse agouti locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr).

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Indication for linkage of the human OB gene region with extreme obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Role of leptin in fat regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

DNA variation in the genes of the Na,K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Neuropeptide Y and energy balance: one way ahead for the treatment of obesity?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Severely impaired adipsin expression in genetic and acquired obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Tissue-specific nutritional regulation of angiotensinogen in adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

A receptor subtype involved in neuropeptide-Y-induced food intake

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Defective STAT signaling by the leptin receptor in diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Peroxisome proliferator-activated receptors: finding the orphan a home

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Weight-reducing effects of the plasma protein encoded by the obese gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Abnormal splicing of the leptin receptor in diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Transcriptional regulation of gene expression during adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Insulin regulates transcription of the CCAAT/enhancer binding protein (C/EBP) alpha, beta, and delta genes in fully-differentiated 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Absence of mutations in the human OB gene in obese/diabetic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Mechanisms for the pleiotropic effects of the agouti gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Effect of fasting on regional levels of neuropeptide Y mRNA and insulin receptors in the rat hypothalamus: An autoradiographic study.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

A candidate gene for the mouse mutation tubby

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Effects of the obese gene product on body weight regulation in ob/ob mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Leptin receptor missense mutation in the fatty Zucker rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

The teleost melanin-concentrating hormone—A pituitary hormone of hypothalamic origin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Extreme obesity may be linked to markers flanking the human OB gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

A novel serum protein similar to C1q, produced exclusively in adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

The role of neuropeptide Y in the antiobesity action of the obese gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and insulin-like growth factor-I.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Targeted disruption of the beta 3-adrenergic receptor gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Prevention of inhibitory effect of free fatty acids on insulin binding and action in isolated rat hepatocytes by etomoxir

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-alpha on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Identification and expression cloning of a leptin receptor, OB-R

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Impaired energy homeostasis in C/EBP alpha knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

CCAAT/Enhancer Binding-Proteins α and β Are Transcriptional Activators of the Brown Fat Uncoupling Protein Gene Promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Positional cloning of the mouse obese gene and its human homologue

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981359-8

7 January 2021

10.1016/S0092-8674(00)81359-8

Identifiers

DOI

1 reference

28 September 2017

1 reference

PubMed ID

8898192