Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase (Q41145264)

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scientific article published on December 1996

Language	Label	Description	Also known as
English	Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase	scientific article published on December 1996

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

author name string

Phillips RM

1

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Europe PubMed Central

PubMed publication ID

27 September 2017

language of work or name

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publication date

1 December 1996

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Europe PubMed Central

PubMed publication ID

27 September 2017

Biochemical Pharmacology

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Europe PubMed Central

PubMed publication ID

27 September 2017

52

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Europe PubMed Central

PubMed publication ID

27 September 2017

11

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Europe PubMed Central

PubMed publication ID

27 September 2017

1711-1718

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Europe PubMed Central

PubMed publication ID

27 September 2017

DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation

1 reference

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7 January 2021

Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism

1 reference

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7 January 2021

Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol

1 reference

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7 January 2021

DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?

1 reference

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7 January 2021

DT-diaphorase and cancer chemotherapy

1 reference

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7 January 2021

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

1 reference

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7 January 2021

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

1 reference

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7 January 2021

Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression

1 reference

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7 January 2021

EO9: relationship between DT-diaphorase levels and response in vitro and in vivo

1 reference

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7 January 2021

Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.

1 reference

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7 January 2021

EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

1 reference

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Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09.

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7 January 2021

The experimental development of bioreductive drugs and their role in cancer therapy.

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7 January 2021

Cytotoxic effects of anticancer agents on subconfluent and multilayered postconfluent cultures

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7 January 2021

Expression of rat liver NAD(P)H:quinone-acceptor oxidoreductase in Escherichia coli and mutagenesis in vitro at Arg-177

1 reference

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7 January 2021

Purification by cibacron blue F3GA dye affinity chromatography and comparison of NAD(P)H:quinone reductase (E.C.1.6.99.2) from rat liver cytosol and microsomes.

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7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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7 January 2021

An agarose gel method for the determination of DNA interstrand crosslinking applicable to the measurement of the rate of total and "second-arm" crosslink reactions

1 reference

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7 January 2021

Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphorase

1 reference

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7 January 2021

In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.

1 reference

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7 January 2021

Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase

1 reference

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7 January 2021

The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

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7 January 2021

The autoxidation of the reduced forms of EO9

1 reference

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7 January 2021

DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.

1 reference

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7 January 2021

Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones

1 reference

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7 January 2021

The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.

1 reference

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7 January 2021

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10.1016/S0006-2952(96)00521-7

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

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