Lack of involvement of reactive oxygen in the cytotoxicity of mitoxantrone, CI941 and ametantrone in MCF-7 cells: comparison with doxorubicin (Q41132585)

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scientific article published on January 1, 1992

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English	Lack of involvement of reactive oxygen in the cytotoxicity of mitoxantrone, CI941 and ametantrone in MCF-7 cells: comparison with doxorubicin	scientific article published on January 1, 1992

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scholarly article

1 reference

Europe PubMed Central

27 September 2017

Lack of involvement of reactive oxygen in the cytotoxicity of mitoxantrone, CI941 and ametantrone in MCF-7 cells: comparison with doxorubicin (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1394801

22 September 2022

1 reference

Europe PubMed Central

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22 September 2022

author name string

G. R. Fisher

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1394801

22 September 2022

L. H. Patterson

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1394801

22 September 2022

language of work or name

1 reference

National Center for Biotechnology Information

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22 September 2022

publication date

1 January 1992

1 reference

Europe PubMed Central

27 September 2017

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

27 September 2017

30

1 reference

Europe PubMed Central

27 September 2017

6

1 reference

Europe PubMed Central

27 September 2017

451-458

1 reference

Europe PubMed Central

27 September 2017

https://scigraph.springernature.com/pub.10.1007/bf00685596

0 references

Mitoxantrone: a new anticancer drug with significant clinical activity

1 reference

https://api.crossref.org/works/10.1007%2FBF00685596

21 January 2018

Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m-anisidide and adriamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of free radicals during the cellular metabolism of adriamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct relation of DNA lesions in multidrug-resistant human myeloma cells to intracellular doxorubicin concentration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of the interaction of anthrapyrazole anticancer agents with deoxyribonucleic acids: structural requirements for DNA binding, intercalation, and photosensitization

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of sodium chloride concentration on adriamycin and N-trifluoroacetyladriamycin-14-valerate (AD32)-induced cell killing and DNA damage in Chinese hamster V79 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells: free radical formation and NAD(P)H: quinone-acceptor oxidoreductase (DT-diaphorase) activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term inhibition of DNA synthesis and the persistence of trapped topoisomerase II complexes in determining the toxicity of the antitumor DNA intercalators mAMSA and mitoxantrone

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitoxantrone affects topoisomerase activities in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fractionation of DNA from mammalian cells by alkaline elution

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of doxorubicin cytotoxicity by ouabain: correlation with topoisomerase-induced DNA strand breakage in human and hamster cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two mechanisms of adriamycin-DNA interaction in L1210 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical lesions in DNA associated with the antiproliferative effects of mitoxantrone in the hepatoma cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen-induced potentiation of DNA damage and cytotoxicity in human breast cancer cells treated with topoisomerase II-interactive antitumor drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistent intracellular binding of mitoxantrone in a human colon carcinoma cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-binding macromolecular lipids from L1210 leukemia tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of mitoxantrone

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of adriamycin-stimulated microsomal lipid peroxidation by mitoxantrone and ametantrone, two new anthracenedione antineoplastic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of DNA scission and cytotoxicity produced by Adriamycin and 5-iminodaunorubicin in human colon carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental antitumor activity of aminoanthraquinones

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxorubicin resistance conferred by selective enhancement of intracellular glutathione peroxidase or superoxide dismutase content in human MCF-7 breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of resistance and characteristics of a human colon carcinoma subline resistant to mitoxantrone in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between cytotoxicity and DNA damage in mammalian cells treated with anthracenedione derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A general mechanism for microsomal activation of quinone anticancer agents to free radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Horseradish peroxidase-catalyzed oxidation of mitoxantrone: spectrophotometric and electron paramagnetic resonance studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance of human melanoma cells against the cytotoxic and complement-enhancing activities of doxorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of DNA breakage in cytotoxicity of doxorubicin, 9-deoxydoxorubicin, and 4-demethyl-6-deoxydoxorubicin in murine leukemia P388 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitoxantrone: propensity for free radical formation and lipid peroxidation--implications for cardiotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitoxantrone-induced DNA damage in leukemia cells is enhanced by treatment with high-dose arabinosylcytosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of adriamycin concentrations to the DNA lesions induced in hypoxic and euoxic L1210 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular uptake and inhibition of DNA synthesis by dihydroxyanthraquinone and two analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of acetylated ferricytochrome C for the detection of superoxide radicals produced in biological membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake and retention of adriamycin and daunorubicin by sensitive and anthracycline-resistant sublines of P388 leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerases

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of the anthrapyrazole biantrazole: clinical results and pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adriamycin-stimulated hydroxyl radical formation in human breast tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative cytotoxicity of bisantrene, mitoxantrone, ametantrone, dihydroxyanthracenedione, dihydroxyanthracenedione diacetate, and doxorubicin on human cells in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of the anthrapyrazole antitumour agent CI941 on rat liver microsome and cytochrome P-450 reductase mediated free radical processes. Inhibition of doxorubicin activation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, biochemical pharmacology, electrochemistry and tumour biology of anti-tumour anthrapyrazoles.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for human liver mediated free-radical formation by doxorubicin and mitozantrone

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the peroxidase-derived metabolite of mitoxantrone with nucleic acids. Evidence for covalent binding of 14C-labeled drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitozantrone-induced toxicity and DNA strand breaks in leukaemic cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorometric quantitation of single-stranded DNA: A method applicable to the technique of alkaline elution

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anthrapyrazoles: true successors to the anthracyclines?

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bis(alkylamino)anthracenedione antineoplastic agent metabolic activation by NADPH-cytochrome P-450 reductase and NADH dehydrogenase: diminished activity relative to anthracyclines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage and cytotoxicity of mitoxantrone and doxorubicin in doxorubicin-sensitive and -resistant human colon carcinoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA strand breakage by peroxidase-activated mitoxantrone

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of hydroxyl radical formation and DNA strand breakage in the cytotoxicity of anthraquinone antitumour agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carrier-mediated transport of daunorubicin, adriamycin, and rubidazone in ehrlich ascites tumour cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of doxorubicin-induced killing of MCF-7 human breast cancer cells by oxygen radical scavengers and iron chelating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for impaired mitoxantrone and vinblastine binding in P388 murine leukemia cells with multidrug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox cycling in MCF-7 human breast cancer cells by antitumor agents based on mitozantrone

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between the pharmacological activity of antitumor drugs Ametantrone and mitoxantrone (Novatrone) and their ability to condense nucleic acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/1394801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00685596

1 reference

Europe PubMed Central

27 September 2017

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0 references

1 reference

Europe PubMed Central

27 September 2017

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