Chimeric proteins can exceed the sum of their parts: implications for evolution and protein design (Q41114221)

26 September 2017

Chimeric proteins can exceed the sum of their parts: implications for evolution and protein design (English)

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26 September 2017

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Campbell RK

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26 September 2017

Bergert ER

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26 September 2017

Wang Y

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26 September 2017

Morris JC

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26 September 2017

Moyle WR

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26 September 2017

language of work or name

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1 May 1997

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26 September 2017

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26 September 2017

15

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26 September 2017

439-443

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26 September 2017

5

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https://scigraph.springernature.com/pub.10.1038/nbt0597-439

26 September 2017

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cites work

Human chorionic gonadotropin promotes thyroid growth via thyrotropin receptors in FRTL-5 cells

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https://api.crossref.org/works/10.1038%2FNBT0597-439

Serum levels of intact human chorionic gonadotropin (HCG) and its free alpha and beta subunits, in relation to maternal thyroid stimulation during normal pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

Glycoprotein Hormones: Structure and Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

The testicular receptor for follicle stimulating hormone: structure and functional expression of cloned cDNA

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Crystal structure of human chorionic gonadotropin

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Structure of human chorionic gonadotropin at 2.6 A resolution from MAD analysis of the selenomethionyl protein

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Studies on structure-function relationships of human choriogonadotropins with C-terminally shortened alpha-subunits. I. Receptor binding and immunologic properties

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Conversion of human choriogonadotropin into a follitropin by protein engineering

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Co-evolution of ligand-receptor pairs

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Effect of peptide nicking in the human chorionic gonadotropin beta-subunit on stimulation of recombinant human thyroid-stimulating hormone receptors

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Carbohydrate Modifications Transform Human Chorionic Gonadotropin into a Potent Stimulator of Adenosine 3′,5′-Monophosphate and Growth Responses in FRTL-5 Thyroid Cells*

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Effect of carboxypeptidase digestion of the human choriogonadotropin molecule on its thyrotropic activity

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Mechanism of thyroid stimulation by human chorionic gonadotropin in sera of normal pregnant women

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

hCG beta residues 94-96 alter LH activity without appearing to make key receptor contacts

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

The groove between the alpha- and beta-subunits of hormones with lutropin (LH) activity appears to contact the LH receptor, and its conformation is changed during hormone binding

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Contribution of subunits to the function of luteinizing hormone/human chorionic gonadotropin recombinants

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Comparison of steroidogenic potencies of homologous and heterologous gonadotropins in rat and mouse Leydig cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

On earlier states of the biochemical system

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Pseudoallelism and gene evolution

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Enzyme recruitment in evolution of new function

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https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

SH2 domain specificity and activity modified by a single residue

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

A single arginine residue determines species specificity of the human growth hormone receptor

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

A single amino acid exchange, Arg-45 to Ala, generates an epidermal growth factor (EGF) mutant with high affinity for the chicken EGF receptor

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

A putative selectivity filter in the G-protein-coupled receptors for parathyroid hormone and secretion

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Use of monoclonal antibodies to subunits of human chorionic gonadotropin to examine the orientation of the hormone in its complex with receptor

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

The effects of synthetic alpha-subunit peptides on thyrotropin interaction with its receptor

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Characterization of the Optimal Stimulatory Effects of Graves’ Monoclonal and Serum Immunoglobulin G on Adenosine 3′,5′-Monophosphate Production in FRTL-5 Thyroid Cells: A Potential Clinical Assay

1 reference

https://api.crossref.org/works/10.1038%2FNBT0597-439

7 January 2021

Identifiers

DOI

10.1038/NBT0597-439

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Dimensions Publication ID

26 September 2017

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