Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases (Q41074727)

26 September 2017

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases (English)

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26 September 2017

3

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31 May 2020

Cristina Cecchi

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31 May 2020

author name string

Elisa Evangelisti

1

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31 May 2020

Roberta Cascella

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31 May 2020

Giovanna Marrazza

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31 May 2020

Fabrizio Chiti

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31 May 2020

Massimo Stefani

7

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31 May 2020

Christopher M Dobson

5

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31 May 2020

language of work or name

English

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publication date

13 September 2016

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26 September 2017

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31 May 2020

volume

6

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31 May 2020

page(s)

32721

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Creative Commons Attribution 4.0 International

31 May 2020

copyright license

start time

13 September 2016

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April 2022 Public Data File from Crossref

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copyrighted

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ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5020652/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/srep32721

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cites work

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

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Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.

26 September 2017

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The amyloid state and its association with protein misfolding diseases.

26 September 2017

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Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes

26 September 2017

1 reference

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The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity

26 September 2017

1 reference

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Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

26 September 2017

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

26 September 2017

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Conserved features of intermediates in amyloid assembly determine their benign or toxic states

26 September 2017

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Direct observation of the interconversion of normal and toxic forms of α-synuclein

26 September 2017

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Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity

26 September 2017

1 reference

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Protein misfolded oligomers: experimental approaches, mechanism of formation, and structure-toxicity relationships

26 September 2017

1 reference

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Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

26 September 2017

1 reference

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Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice

26 September 2017

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A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells

26 September 2017

1 reference

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Amyloidogenic protein-membrane interactions: mechanistic insight from model systems

26 September 2017

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Calcium signaling and amyloid toxicity in Alzheimer disease

26 September 2017

1 reference

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Lipid rafts: keys to neurodegeneration

26 September 2017

1 reference

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Size-dependent neurotoxicity of beta-amyloid oligomers.

26 September 2017

1 reference

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Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

26 September 2017

1 reference

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A causative link between the structure of aberrant protein oligomers and their toxicity.

26 September 2017

1 reference

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

26 September 2017

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Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity

26 September 2017

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Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

26 September 2017

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Calcium dysregulation in Alzheimer's disease

26 September 2017

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Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicity.

26 September 2017

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Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers

26 September 2017

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Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

26 September 2017

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Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death

26 September 2017

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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

26 September 2017

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Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)

26 September 2017

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Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

26 September 2017

1 reference

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Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates.

26 September 2017

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Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide

26 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Regulation of cell death: the calcium-apoptosis link

26 September 2017

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

26 September 2017

1 reference

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Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Lipid raft disruption protects mature neurons against amyloid oligomer toxicity

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Susceptibility of hippocampal neurons to Abeta peptide toxicity is associated with perturbation of Ca2+ homeostasis

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Alzheimer's disease (AD) as a disorder of the plasma membrane

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Altered distribution of the gangliosides GM1 and GM2 in Alzheimer's disease.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Alzheimer's disease. Fresh evidence points to an old suspect: calcium.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Fluorescent biosensor for quantitative real-time measurements of inositol 1,4,5-trisphosphate in single living cells

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5020652

An improved fluorescence assay for the determination of lymphocyte-mediated cytotoxicity using flow cytometry

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27619987

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gangliosides and sulphatide in human cerebrospinal fluid: quantitation with immunoaffinity techniques

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27619987

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP32721

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27619987%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

31 May 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27619987%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference