Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice. (Q41045084)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26251044%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice (English)

1 reference

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21 February 2020

1 reference

5

1 reference

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21 February 2020

Carmine Nicoletti

6

1 reference

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21 February 2020

Angela Catizone

9

1 reference

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21 February 2020

Fabrizio De Benedetti

10

1 reference

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21 February 2020

Antonio Musarò

11

1 reference

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21 February 2020

author name string

Laura Pelosi

1

1 reference

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21 February 2020

Maria Grazia Berardinelli

2

1 reference

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21 February 2020

Laura Forcina

3

1 reference

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21 February 2020

Elisa Spelta

4

1 reference

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21 February 2020

Carlotta Camilli

7

1 reference

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21 February 2020

Erika Testa

8

1 reference

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21 February 2020

publication date

6 August 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26251044%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

published in

Human Molecular Genetics

1 reference

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21 February 2020

volume

24

1 reference

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21 February 2020

page(s)

6041-6053

1 reference

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21 February 2020

issue

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26251044%20AND%20SRC:MED&resulttype=core&format=json

Functional and Morphological Improvement of Dystrophic Muscle by Interleukin 6 Receptor Blockade.

21 February 2020

cites work

1 reference

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STAT3 signaling controls satellite cell expansion and skeletal muscle repair

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Inhibition of JAK-STAT signaling stimulates adult satellite cell function.

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Assessment of murine exercise endurance without the use of a shock grid: an alternative to forced exercise

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IL-6 impairs myogenic differentiation by downmodulation of p90RSK/eEF2 and mTOR/p70S6K axes, without affecting AKT activity

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Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting

26 September 2017

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Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice

26 September 2017

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Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?

26 September 2017

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Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice

26 September 2017

1 reference

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Muscle side population cells from dystrophic or injured muscle adopt a fibro-adipogenic fate

26 September 2017

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IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6.

26 September 2017

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Tissue-specific stem cells: lessons from the skeletal muscle satellite cell

26 September 2017

1 reference

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IL-6/IL-6 receptor system and its role in physiological and pathological conditions

26 September 2017

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Activation of NF-kappaB pathway in Duchenne muscular dystrophy: relation to age.

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Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB

26 September 2017

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Enhancing translation: guidelines for standard pre-clinical experiments in mdx mice

26 September 2017

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Mechanisms inducing low bone density in Duchenne muscular dystrophy in mice and humans

26 September 2017

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Interleukin 6 as a key regulator of muscle mass during cachexia

26 September 2017

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Interleukin-6 contributes to age-related alteration of cytokine production by macrophages

26 September 2017

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Immune-mediated mechanisms potentially regulate the disease time-course of duchenne muscular dystrophy and provide targets for therapeutic intervention

26 September 2017

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Impact of ageing on muscle cell regeneration

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26 September 2017

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Muscle as an endocrine organ: focus on muscle-derived interleukin-6.

26 September 2017

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Self-renewal and expansion of single transplanted muscle stem cells

26 September 2017

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Sca-1-expressing nonmyogenic cells contribute to fibrosis in aged skeletal muscle

26 September 2017

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Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy

26 September 2017

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Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy

26 September 2017

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26 September 2017

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Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

26 September 2017

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Interleukin-6 and chronic inflammation

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Muscle regeneration in dystrophin-deficient mdx mice studied by gene expression profiling

26 September 2017

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Sca-1 negatively regulates proliferation and differentiation of muscle cells.

26 September 2017

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IKKbeta/NF-kappaB activation causes severe muscle wasting in mice

26 September 2017

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Duchenne muscular dystrophy and dystrophin: pathogenesis and opportunities for treatment

26 September 2017

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SOCS3 regulates the plasticity of gp130 signaling

26 September 2017

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SOCS3 negatively regulates IL-6 signaling in vivo

26 September 2017

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26 September 2017

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A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice

26 September 2017

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Pax7 is required for the specification of myogenic satellite cells

26 September 2017

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NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia

26 September 2017

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26 September 2017

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Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation

26 September 2017

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The relationship between weight loss and interleukin 6 in non-small-cell lung cancer

26 September 2017

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Interleukin-6 induces skeletal muscle protein breakdown in rats

26 September 2017

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Satellite cell proliferation and the expression of myogenin and desmin in regenerating skeletal muscle: evidence for two different populations of satellite cells.

26 September 2017

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Inflammatory cell response to acute muscle injury.

26 September 2017

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The good, the bad, and the ugly of interleukin-6 signaling.

26 September 2017

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IL-6-induced skeletal muscle atrophy

14 June 2018

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Muscular dystrophy in the mdx mouse: histopathology of the soleus and extensor digitorum longus muscles.

14 June 2018

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Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy.

14 June 2018

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Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle.

19 August 2018

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Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

19 August 2018

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Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

19 August 2018

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Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: a comparison study with methylprednisolone.

19 August 2018

1 reference

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Measuring mechanical properties, including isotonic fatigue, of fast and slow MLC/mIgf-1 transgenic skeletal muscle.

19 August 2018

1 reference

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Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice

19 August 2018

1 reference

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Chronic treatment with agents that stabilize cytosolic IkappaB-alpha enhances survival and improves resting membrane potential in MDX muscle fibers subjected to chronic passive stretch

19 August 2018

1 reference

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Steep elevation of blood interleukin-6 (IL-6) associated only with late stages of cachexia in cancer patients.

19 August 2018

1 reference

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AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise

19 August 2018

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Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins

19 August 2018

1 reference

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ATP regulation of calcium binding in Ca2+-ATPase molecules of the sarcoplasmic reticulum

19 August 2018

1 reference

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Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy.

19 August 2018

1 reference

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Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1.

19 August 2018

1 reference

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Evans Blue Dye as an in vivo marker of myofibre damage: optimising parameters for detecting initial myofibre membrane permeability.

19 August 2018

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Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content.

19 August 2018

1 reference

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Visualization of dystrophic muscle fibers in mdx mouse by vital staining with Evans blue: evidence of apoptosis in dystrophin-deficient muscle.

19 August 2018

1 reference

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Gene expression profiling in the early phases of DMD: a constant molecular signature characterizes DMD muscle from early postnatal life throughout disease progression

19 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FHMG%2FDDV323

Common pathological mechanisms in mouse models for muscular dystrophies

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FHMG%2FDDV323

The Basis of Muscle Regeneration

21 January 2018

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The mdx mouse skeletal muscle myopathy: II. Contractile properties

21 January 2018

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12 December 2020

Muscle undergoes atrophy in association with increase of lysosomal cathepsin activity in interleukin-6 transgenic mouse

1 reference

12 December 2020

Serum creatine-kinase (CK) and pyruvate-kinase (PK) activities in Duchenne (DMD) as compared with Becker (BMD) muscular dystrophy

1 reference

12 December 2020

Growing muscle has different sarcolemmal properties from adult muscle: a proposal with scientific and clinical implications: reasons to reassess skeletal muscle molecular dynamics, cellular responses and suitability of experimental models of muscle

1 reference

12 December 2020

Pre-clinical screening of drugs using the mdx mouse

1 reference

12 December 2020

Leukemia inhibitory factor and interleukin-6 are produced by diseased and regenerating skeletal muscle

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12 December 2020

First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant

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12 December 2020

MyoD, myogenin, and desmin-nls-lacZ transgene emphasize the distinct patterns of satellite cell activation in growth and regeneration

1 reference

12 December 2020

Evidence ofmdx mouse skeletal muscle fragility in vivo by eccentric running exercise

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDV323

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26251044%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26251044%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26251044%20AND%20SRC:MED&resulttype=core&format=json