A statistical guide to the design of deep mutational scanning experiments (Q41021919)

25 September 2017

A statistical guide to the design of deep mutational scanning experiments (English)

1 reference

25 September 2017

1 reference

deep mutational scanning

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author

Jeffrey D. Jensen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Sebastian Matuszewski

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Ana-Hermina Ghenu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Claudia Bank

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Marcel E Hildebrandt

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

English

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publication date

13 July 2016

1 reference

25 September 2017

11

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based on heuristic

inferred from page(s)

published in

Genetics

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

204

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

77-87

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

Local fitness landscape of the green fluorescent protein

10 June 2020

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1 reference

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26 September 2017

1 reference

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The Utility of Fisher's Geometric Model in Evolutionary Genetics

26 September 2017

1 reference

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A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

26 September 2017

1 reference

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Distribution of mutational fitness effects and of epistasis in the 5' untranslated region of a plant RNA virus

26 September 2017

1 reference

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Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli

26 September 2017

1 reference

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High-resolution sequence-function mapping of full-length proteins

26 September 2017

1 reference

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The evolutionarily stable distribution of fitness effects

26 September 2017

1 reference

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A systematic survey of an intragenic epistatic landscape.

26 September 2017

1 reference

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Deep mutational scanning: a new style of protein science

26 September 2017

1 reference

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Effects of new mutations on fitness: insights from models and data

26 September 2017

1 reference

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Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast

26 September 2017

1 reference

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A comprehensive, high-resolution map of a gene's fitness landscape

26 September 2017

1 reference

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The fates of mutant lineages and the distribution of fitness effects of beneficial mutations in laboratory budding yeast populations

26 September 2017

1 reference

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A bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environments

26 September 2017

1 reference

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Shifting fitness landscapes in response to altered environments.

26 September 2017

1 reference

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Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein

26 September 2017

1 reference

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High-throughput analysis of in vivo protein stability

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

Capturing the mutational landscape of the beta-lactamase TEM-1.

26 September 2017

1 reference

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Latent effects of Hsp90 mutants revealed at reduced expression levels

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

Analyses of the effects of all ubiquitin point mutants on yeast growth rate

26 September 2017

1 reference

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TALENs: a widely applicable technology for targeted genome editing

26 September 2017

1 reference

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Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening

26 September 2017

1 reference

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

26 September 2017

1 reference

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Fitness analyses of all possible point mutations for regions of genes in yeast

26 September 2017

1 reference

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Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

26 September 2017

1 reference

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A method for inferring the rate of occurrence and fitness effects of advantageous mutations

26 September 2017

1 reference

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High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

26 September 2017

1 reference

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Experimental illumination of a fitness landscape

26 September 2017

1 reference

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High-resolution mapping of protein sequence-function relationships

26 September 2017

1 reference

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What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?

26 September 2017

1 reference

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Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies

26 September 2017

1 reference

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Fitness and its role in evolutionary genetics

26 September 2017

1 reference

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An approximate bayesian estimator suggests strong, recurrent selective sweeps in Drosophila

26 September 2017

1 reference

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The distribution of fitness effects of new mutations

26 September 2017

1 reference

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A general multivariate extension of Fisher's geometrical model and the distribution of mutation fitness effects across species

26 September 2017

1 reference

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Model of effectively neutral mutations in which selective constraint is incorporated

26 September 2017

1 reference

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Theories of adaptation: what they do and don't say.

26 September 2017

1 reference

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An empirical test of the mutational landscape model of adaptation using a single-stranded DNA virus

26 September 2017

1 reference

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The genetic theory of adaptation: a brief history

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

Fitness effects of advantageous mutations in evolving Escherichia coli populations

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

The pattern of neutral molecular variation under the background selection model

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

Network of epistatic interactions within a yeast snoRNA.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

The distribution of fitness effects in an uncertain world

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

The fitness landscape of a tRNA gene.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

Evolution of clonal populations approaching a fitness peak.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

Cost of antibiotic resistance and the geometry of adaptation.

19 August 2018

1 reference

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The fitness effect of mutations across environments: a survey in light of fitness landscape models.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

Fitness effects of fixed beneficial mutations in microbial populations.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

The fate of competing beneficial mutations in an asexual population.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012406

THE POPULATION GENETICS OF ADAPTATION: THE DISTRIBUTION OF FACTORS FIXED DURING ADAPTIVE EVOLUTION.

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27412710

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A simple stochastic gene substitution model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27412710

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1534/GENETICS.116.190462

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27412710%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference