Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1-42 induced neurotoxicity and memory impairment. (Q40944905)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27142962%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

title

Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1-42 induced neurotoxicity and memory impairment (English)

1 reference

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3 April 2020

1 reference

9

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Paula Maria Quaglio Bellozi

3 April 2020

1

1 reference

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3 April 2020

Antonio L Teixeira

8

1 reference

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3 April 2020

7

Helton José Reis

1 reference

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3 April 2020

author name string

Isabel Vieira de Assis Lima

2

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3 April 2020

Juliana Guimarães Dória

3

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3 April 2020

Érica Leandro Marciano Vieira

4

1 reference

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3 April 2020

Alline Cristina Campos

5

1 reference

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3 April 2020

Eduardo Candelario-Jalil

6

1 reference

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3 April 2020

Antônio Carlos Pinheiro de Oliveira

10

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3 April 2020

language of work or name

English

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publication date

4 May 2016

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3 April 2020

1 reference

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3 April 2020

volume

6

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3 April 2020

page(s)

25226

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Creative Commons Attribution 4.0 International

3 April 2020

copyright license

start time

4 May 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4855228/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/srep25226

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Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP

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mTOR complexes in neurodevelopmental and neuropsychiatric disorders

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Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not β-amyloid in cognitively normal older individuals

25 September 2017

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Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal carcinoma

25 September 2017

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PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease

25 September 2017

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Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus

25 September 2017

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Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer's disease

25 September 2017

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Interleukin-6, a major cytokine in the central nervous system

25 September 2017

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Targeting disease through novel pathways of apoptosis and autophagy

25 September 2017

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25 September 2017

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Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology

25 September 2017

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Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay

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Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease

25 September 2017

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False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine.

25 September 2017

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The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses

25 September 2017

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Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease?

25 September 2017

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Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses

25 September 2017

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AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice

25 September 2017

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Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice.

25 September 2017

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Physiology of microglia

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Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

25 September 2017

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Ghrelin ameliorates cognitive dysfunction and neurodegeneration in intrahippocampal amyloid-β1-42 oligomer-injected mice

25 September 2017

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25 September 2017

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Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway

25 September 2017

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Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

25 September 2017

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Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts.

25 September 2017

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The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events

25 September 2017

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A complex interplay between Akt, TSC2 and the two mTOR complexes

25 September 2017

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NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

25 September 2017

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Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

25 September 2017

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

25 September 2017

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Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one

25 September 2017

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TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study

25 September 2017

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Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons

25 September 2017

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Inflammation and Alzheimer's disease

25 September 2017

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Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

25 September 2017

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

25 September 2017

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25 September 2017

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Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

25 September 2017

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IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.

25 September 2017

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Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses

17 June 2018

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Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in β-amyloid rat model of Alzheimer's disease

17 June 2018

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Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice.

17 June 2018

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The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor

17 June 2018

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Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.

17 June 2018

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The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

17 June 2018

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PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine.

17 June 2018

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Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans.

19 August 2018

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RIPK3 as a potential therapeutic target for Gaucher's disease.

19 August 2018

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Discovering and targeting the basic mechanism of neurodegeneration: the role of peptides from the C-terminus of acetylcholinesterase: non-hydrolytic effects of ache: the actions of peptides derived from the C-terminal and their relevance to neurodeg

19 August 2018

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Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease

19 August 2018

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PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis.

19 August 2018

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PI3K mediates stretch-induced COX-2 expression during urinary tract obstruction

19 August 2018

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A review: inflammatory process in Alzheimer's disease, role of cytokines.

19 August 2018

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DMXB (GTS-21) ameliorates the cognitive deficits in beta amyloid(25-35(-) ) injected mice through preventing the dysfunction of alpha7 nicotinic receptor

19 August 2018

1 reference

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Differential susceptibility following beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response.

19 August 2018

1 reference

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Characteristics of object location memory in mice: Behavioral and pharmacological studies.

19 August 2018

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Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat.

19 August 2018

1 reference

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Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus

19 August 2018

1 reference

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Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo

19 August 2018

1 reference

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Spatial memory, habituation, and reactions to spatial and nonspatial changes in rats with selective lesions of the hippocampus, the entorhinal cortex or the subiculum.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855228

Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27142962

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP25226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27142962%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27142962%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference