C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin (Q40912777)

24 September 2017

C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin (English)

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24 September 2017

Tomita T

1

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24 September 2017

Takikawa R

2

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24 September 2017

Koyama A

3

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24 September 2017

Morohashi Y

4

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24 September 2017

Takasugi N

5

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24 September 2017

Saido TC

6

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24 September 2017

Maruyama K

7

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24 September 2017

Iwatsubo T

8

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24 September 2017

language of work or name

English

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publication date

1 December 1999

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24 September 2017

Journal of Neuroscience

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24 September 2017

19

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24 September 2017

24

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24 September 2017

10627-10634

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

24 September 2017

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12 December 2020

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

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12 December 2020

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

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12 December 2020

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

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12 December 2020

A five-residue sequence near the carboxyl terminus of the polytopic membrane protein lac permease is required for stability within the membrane

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12 December 2020

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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12 December 2020

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

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12 December 2020

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

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12 December 2020

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

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12 December 2020

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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12 December 2020

Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.

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12 December 2020

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

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12 December 2020

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

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12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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12 December 2020

Refolding of an integral membrane protein. Denaturation, renaturation, and reconstitution of intact bacteriorhodopsin and two proteolytic fragments

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12 December 2020

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

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12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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12 December 2020

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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12 December 2020

Presenilin is required for activity and nuclear access of Notch in Drosophila

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

The molecular pathology of Alzheimer's disease

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12 December 2020

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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12 December 2020

Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

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12 December 2020

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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12 December 2020

The Alzheimer family of diseases: many etiologies, one pathogenesis?

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12 December 2020

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

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12 December 2020

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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12 December 2020

Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

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12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

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12 December 2020

Long amyloid beta-protein secreted from wild-type human neuroblastoma IMR-32 cells

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12 December 2020

Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas

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12 December 2020

Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

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12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

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12 December 2020

Protein topology of presenilin 1

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12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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12 December 2020

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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12 December 2020

Carboxyl-terminal truncations of the melibiose carrier of Escherichia coli.

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12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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12 December 2020

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

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12 December 2020

Identifiers

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