Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B. (Q40911261)

24 September 2017

Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B. (English)

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24 September 2017

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P Smart

1

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24 September 2017

E B Lane

2

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24 September 2017

D P Lane

3

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24 September 2017

C Midgley

4

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24 September 2017

B Vojtesek

5

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24 September 2017

S Laín

6

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24 September 2017

language of work or name

English

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publication date

1 December 1999

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24 September 2017

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24 September 2017

18

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24 September 2017

51

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24 September 2017

7378-7386

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203260

24 September 2017

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Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

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7 January 2021

Functions of the MDM2 oncoprotein

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Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies

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Limitation of therapy in the treatment of childhood cancer: toxicity versus cure

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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

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Cell-cycle regulators and cancer

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An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

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Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage

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7 January 2021

Nucleocytoplasmic transport: the soluble phase

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Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

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7 January 2021

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

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Phase I trial of elactocin

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Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

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7 January 2021

In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721).

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1-(5-Isoquinolinesulfonyl)-2-methylpiperazine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway

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Exportin 1 (Crm1p) is an essential nuclear export factor

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

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Novel antitumor antibiotics, CI-940 (PD 114,720) and PD 114,721. Taxonomy, fermentation and biological activity.

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Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs

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7 January 2021

Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203260

1 reference

Dimensions Publication ID

24 September 2017

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1 reference