JNK2 and IKKbeta are required for activating the innate response to viral infection (Q40907787)

24 September 2017

JNK2 and IKKbeta are required for activating the innate response to viral infection (English)

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24 September 2017

B Williams

7

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author name string

W M Chu

1

1 reference

24 September 2017

D Ostertag

2

1 reference

24 September 2017

Z W Li

3

1 reference

24 September 2017

L Chang

4

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24 September 2017

Y Chen

5

1 reference

24 September 2017

Y Hu

6

1 reference

24 September 2017

J Perrault

8

1 reference

24 September 2017

M Karin

9

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24 September 2017

language of work or name

English

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publication date

1 December 1999

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24 September 2017

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24 September 2017

11

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24 September 2017

721-731

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24 September 2017

6

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Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

24 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

NF-kappaB activation Is delayed in mouse L929 cells infected with interferon suppressing, but not inducing, vesicular stomatitis virus strains

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

The double-stranded RNA-dependent protein kinase PKR: structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Defective T Cell Differentiation in the Absence of Jnk1

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Transcription factor ATF2 regulation by the JNK signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Phylogenetic perspectives in innate immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Signaling by the cytokine receptor superfamily: JAKs and STATs.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

The regulation of AP-1 activity by mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

The war against the interferon-induced dsRNA-activated protein kinase: can viruses win?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

The stress-activated protein kinase subfamily of c-Jun kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

The interferon-induced double-stranded RNA-activated human p68 protein kinase inhibits the replication of vaccinia virus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Different pathways mediate virus inducibility of the human IFN-alpha 1 and IFN-beta genes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Signal transduction through NF-kappa B.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Innate immunity: the virtues of a nonclonal system of recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Functional role of type I and type II interferons in antiviral defense

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Human cytomegalovirus induces IL-6 and TNF alpha from macrophages and microglial cells: possible role in neurotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Identification and characterization of an IkappaB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Regulation of type I interferon gene expression by interferon regulatory factor-3.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

JNK is involved in signal integration during costimulation of T lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Limb and skin abnormalities in mice lacking IKKalpha

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

2-Aminopurine selectively inhibits the induction of beta-interferon, c-fos, and c-myc gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980146-6

7 January 2021

10.1016/S1074-7613(00)80146-6

Identifiers

DOI

1 reference

24 September 2017

1 reference