The Flinders sensitive line rats: a genetic animal model of depression (Q40887716)

24 September 2017

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title

The Flinders sensitive line rats: a genetic animal model of depression (English)

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24 September 2017

Overstreet DH

1

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PubMed ID

8455816

24 September 2017

language of work or name

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1 January 1993

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Neuroscience & Biobehavioral Reviews

24 September 2017

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24 September 2017

17

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24 September 2017

1

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24 September 2017

51-68

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Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims.

24 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects

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7 January 2021

CSF monoamine metabolites in melancholia

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https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Rat strain differences in response to dark pulse triggering of paradoxical sleep.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

The cholinergic rapid eye movement sleep induction test with RS-86. State or trait marker of depression?

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Commentary on mood and memory

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Depression, suicide, and aggression in alcoholics and their relationship to plasma amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Nicotine dependence, major depression, and anxiety in young adults

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Contribution of the depressive perspective to memory function in depression.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Down-regulation of beta-adrenergic receptors following repeated injections of desmethylimipramine: permissive role of serotonergic axons.

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7 January 2021

Olfactory projection systems, drugs and behaviour: A review

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https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories

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https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Neuroendocrine regulation in depression. I. Limbic system-adrenocortical dysfunction.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Long-term lithium treatment selectively reduces receptor-coupled inositol phospholipid hydrolysis in rat brain

1 reference

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7 January 2021

Alterations in corticotropin-releasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress

1 reference

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7 January 2021

Tolerance to low acetylcholinesterase levels: Modification of behavior without acute behavioral change

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7 January 2021

The biochemistry of affective disorders

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7 January 2021

A dopamine-5-hydroxytryptamine link in the hypothalamic pathways which mediate heat loss in the rat.

1 reference

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7 January 2021

Dopamine sensitivity in rats selectively bred for increases in cholinergic function.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Mitogen-stimulated lymphocyte proliferation and pituitary hormones in major depression

1 reference

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7 January 2021

Diagnostic subgroups of affective disorders and their urinary excretion of catecholamine metabolities

1 reference

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7 January 2021

Relation between the thermoregulatory effects of intracerebroventricularly injected dopamine and 5-hydroxytryptamine in the rabbit

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7 January 2021

Neurobiologic effects of bright artificial light

1 reference

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7 January 2021

Amitriptyline-induced supersensitivity of a central muscarinic mechanism: lithium blocks amitriptyline-induced supersensitivity

1 reference

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7 January 2021

Bright artificial light subsensitizes a central muscarinic mechanism

1 reference

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7 January 2021

Bright light blocks amitriptyline-induced cholinoceptor supersensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

The Flinders Sensitive Line exhibits enhanced thermic responsiveness to nicotine relative to the Sprague-Dawley rat

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Update on the dementia spectrum of depression

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Cholinergic modulation of adrenergic arousal in the developing rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Catecholamine systems as the neural substrate for intracranial self-stimulation: a hypothesis

1 reference

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7 January 2021

CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa

1 reference

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7 January 2021

Motor effects of serotonin in the central nervous system

1 reference

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7 January 2021

Successful Separation of Depressed, Normal, and Insomniac Subjects by EEG Sleep Data

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7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

ACTH and multisteroid responses to corticotropin-releasing factor in depressive illness: Relationship to multisteroid responses after ACTH stimulation and dexamethasone suppression☆

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Reduction of immune function in life stress and depression

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

A cholinergic-adrenergic hypothesis of mania and depression

1 reference

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7 January 2021

Antagonistic Effects of Physostigmine and Methylphenidate in Man

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https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Animal models of depression: parallels and correlates to severe depression in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Retinohypothalamic projections in the hamster and rat demonstrated using cholera toxin

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Animal models and human depressive disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Muscarinic binding in suicides

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Cholinergic-dopaminergic interactions in experimental catalepsy

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Evidence for a cholinergic role in haloperidol-induced catalepsy

1 reference

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7 January 2021

Drug effects on active immobility responses: what they tell us about neurotransmitter systems and motor functions

1 reference

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7 January 2021

Brain serotonergic neurons: Their role in a form of dominance-subordination behavior in rats

1 reference

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7 January 2021

Changes of acetylcholinesterase activity in three major brain areas and related changes in behaviour following acute treatment with diisopropyl fluorophosphate.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Controlled trial of bright light for nonseasonal major depressive disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Studies on the role of brain cholinergic systems in the therapeutic mechanisms and adverse effects of ECT and lithium.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

5-HT1A receptor function in depression: effect of chronic amitriptyline treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Heritability of dark pulse triggering of paradoxical sleep in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Increased serotonin2 and beta-adrenergic receptor binding in the frontal cortices of suicide victims

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressants.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Cognitive functioning in the affective disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Human brain receptor alterations in suicide victims

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Increased 5-HT-2 receptor function as measured by serotonin-stimulated phosphoinositide hydrolysis in platelets of depressed patients

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

GABA, depression and the mechanism of action of antidepressant drugs: a neuroendocrine approach.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

The role of corticotropin-releasing factor in the pathogenesis of major depression

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Effects of cholinergic agonists and antagonists on self-stimulation behavior in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Measuring cholinergic sensitivity: I. Arecoline effects in bipolar patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Selective breeding for increased cholinergic function: development of a new animal model of depression.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Commentary: A behavioral, psychopharmacological, and neurochemical update on the flinders sensitive line rat, a potential genetic animal model of depression

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Selective breeding for diisopropyl fluorophosphate-sensitivity: behavioural effects of cholinergic agonists and antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Enhanced elevation of corticosterone following arecoline administration to rats selectively bred for increased cholinergic function.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Effects of bright light on responsiveness to a muscarinic agonist in rats selectively bred for endogenously increased cholinergic function.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Stress-induced immobility in rats with cholinergic supersensitivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Impaired active avoidance responding in rats selectively bred for increased cholinergic function.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Selective breeding for differences in cholinergic function: pre- and postsynaptic mechanisms involved in sensitivity to the anticholinesterase, DFP

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Genetic and pharmacological models of cholinergic supersensitivity and affective disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Selective breeding for sensitivity to the anticholinesterase DFP

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Antidepressant effects of rolipram in a genetic animal model of depression: cholinergic supersensitivity and weight gain

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Enhanced benzodiazepine responsiveness in rats with increased cholinergic function.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

GABAergic modulation of learned helplessness

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

L-tryptophan in mania. Contribution to a permissive hypothesis of affective disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Enhanced affective aggression in genetically bred hypercholinergic rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Biochemical and pharmacological evidence for central cholinergic regulation of shock-induced aggression in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

A study to assess the anticholinergic activity of rolipram in healthy elderly volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Mechanisms underlying sensitivity to organophosphorus anticholinesterase compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Selective breeding for sensitivity to DFP: generalization of effects beyond criterion variables

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

The catecholamine hypothesis of affective disorders: a review of supporting evidence

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Lack of anxiety in an animal model of depression with cholinergic supersensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Immobility-reducing effects of antidepressants in a genetic animal model of depression

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

3-Methoxy-4-hydroxyphenylglycol in depression

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Additivity of neurochemical changes in learned helplessness and imipramine

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Acetylcholine and the regulation of REM sleep: basic mechanisms and clinical implications for affective illness and narcolepsy

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Increased REM sleep in rats selectively bred for cholinergic hyperactivity

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Diurnal rhythm of core body temperature is phase advanced in a rodent model of depression.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Studies of a possible relationship of brain proteins to changes in behavioral sensitivity to DFP

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

The association of supersensitive cholinergic REM-induction and affective illness within pedigrees.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Depression, the immune system, and health and illness. Findings in search of meaning

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

New perspectives on the molecular pharmacology of affective disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Monoamines and abnormal behaviour. A multi-aminergic perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Dysbalance of neuronal second messenger function in the aetiology of affective disorders: a pathophysiological concept hypothesising defects beyond first messenger receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Absence of anticholinergic activity of rolipram, an antidepressant with a novel mechanism of action, in three different animal models in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Selective breeding for increased cholinergic function: increased serotonergic sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Circadian rhythm mechanisms in affective illness and in antidepressant drug action

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Dopamine and depression: A review of recent evidence. I. Empirical studies

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

The validity of animal models of depression

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Animal models of depression: an overview

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Motor activity and affective illness. The relationship of amplitude and temporal distribution to changes in affective state

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Presynaptic modulation of transmitter release by nicotinic receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

5HT2 receptor changes in major depression.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

Region-specific reductions of intracranial self-stimulation after uncontrollable stress: possible effects on reward processes.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

1 reference

7 January 2021

Rate of forgetting in dementia and depression.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980230-1

7 January 2021

10.1016/S0149-7634(05)80230-1

Identifiers

DOI

1 reference

24 September 2017

1 reference

PubMed ID

8455816