The structure, function, and regulation of cytochrome P450 2A enzymes (Q40873491)

24 September 2017

1 reference

title

The structure, function, and regulation of cytochrome P450 2A enzymes (English)

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24 September 2017

P Honkakoski

1

1 reference

PubMed ID

9421682

24 September 2017

M Negishi

series ordinal

2

1 reference

PubMed ID

9421682

24 September 2017

language of work or name

English

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publication date

1 November 1997

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24 September 2017

Drug Metabolism Reviews

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24 September 2017

29

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24 September 2017

977-996

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24 September 2017

4

1 reference

The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis

24 September 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Multiple steroid-binding orientations: alteration of regiospecificity of dehydroepiandrosterone 2- and 7-hydroxylase activities of cytochrome P-450 2a-5 by mutation of residue 209.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific carcinogen, by rabbit nasal microsomes and cytochrome P450s NMa and NMb

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Posttranscriptional regulation of coumarin 7-hydroxylase induction by xenobiotics in mouse liver: mRNA stabilization by pyrazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Nasal Cavity Enzymes Involved in Xenobiotic Metabolism: Effects on the Toxicity of Inhalants

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Identification and biochemical analysis of novel olfactory-specific cytochrome P-450IIA and UDP-glucuronosyl transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Testosterone-mediated regulation of mouse renal cytochrome P-450 isoenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Identification of cytochromes P450 1A2, 2A1, 2C7, 2E1 in rat glioma C6 cell line by RT-PCR and specific restriction enzyme digestion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Regulation of liver-specific steroid metabolizing cytochromes P450: cholesterol 7α-hydroxylase, bile acid 6β-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

The role and mechanism of growth hormone in the regulation of sexually dimorphic P450 enzymes in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Structure and in vitro transcription of the rat CYP2A1 and CYP2A2 genes and regional localization of the CYP2A gene subfamily on mouse chromosome 7

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

A STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid 6 beta-hydroxylase gene expression by growth hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Cytochrome P4502A5 expression and inducibility by phenobarbital is modulated by cAMP in mouse primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Localization of a phenobarbital-responsive element (PBRE) in the 5'-flanking region of the rat CYP2B2 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

The cerium-induced liver injury and oxidative drug metabolism in DBA/2 and C57BL/6 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Selective induction of coumarin 7-hydroxylase by pyrazole in D2 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

High expression of cytochrome P450 2a-5 (coumarin 7-hydroxylase) in mouse hepatomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Complete cDNA sequence of a major 3-methylcholanthrene-inducible cytochrome P-450 isozyme (P-450AFB) of Syrian hamsters with high activity toward aflatoxin B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Reciprocal size-effect relationship of the key residues in determining regio- and stereospecificities of DHEA hydroxylase activity in P450 2a5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Mouse steroid 15.alpha.-hydroxylase gene family: identification of type II P-45015.alpha. as coumarin 7-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709002240

10.3109/03602539709002240

21 January 2018

Identifiers

DOI

1 reference

24 September 2017

1 reference

PubMed ID

9421682