c-Cbl is a suppressor of the neu oncogene (Q40862177)

24 September 2017

c-Cbl is a suppressor of the neu oncogene (English)

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24 September 2017

G Levkowitz

1

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24 September 2017

S Oved

2

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24 September 2017

L N Klapper

3

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24 September 2017

D Harari

4

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24 September 2017

S Lavi

5

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24 September 2017

M Sela

6

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24 September 2017

Y Yarden

7

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24 September 2017

language of work or name

English

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publication date

1 November 2000

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Journal of Biological Chemistry

24 September 2017

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24 September 2017

275

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24 September 2017

35532-35539

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24 September 2017

45

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Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

24 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Amplification of a novel v-erbB-related gene in a human mammary carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively active

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Activated neu induces rapid tumor progression.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002661200

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Involvement of pp60c-src with two major signaling pathways in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Roles for a cytoplasmic tyrosine and tyrosine kinase activity in the interactions of Neu receptors with coated pits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Basic fibroblast growth factor fused to a signal peptide transforms cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Transcriptional regulation by extracellular signals: mechanisms and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Clonal cell lines from the rat central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Alternative intracellular routing of ErbB receptors may determine signaling potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Ligand-induced transformation by a noninternalizing epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

Decreased protein levels of the c-Cbl protooncogene in murine AIDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002661200

21 January 2018

Identifiers

DOI

10.1074/JBC.M002661200

1 reference

24 September 2017

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