Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta. (Q40837781)

From Wikidata

Jump to navigation Jump to search

scientific article

Language	Label	Description	Also known as
English	Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

author name string

Adnane J

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Bizouarn FA

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Chen Z

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Hamilton AD

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Munoz-Antonia T

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Sebti SM

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

language of work or name

0 references

publication date

1 November 2000

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

number of pages

9

1 reference

based on heuristic

inferred from page(s)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

19

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

48

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

5525-5533

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11114730%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1203920

0 references

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Protein prenyltransferases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Independent changes in type I and type II receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Involvement of protein kinase C and rho GTPase in the nuclear signalling pathway by transforming growth factor-beta1 in rat-2 fibroblast cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Smads: transcriptional activators of TGF-beta responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Transforming growth factor-beta signaling in epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

The role of transforming growth factor beta in glioma progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Development of TGF-beta resistance during malignant progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Farnesyltransferase inhibitors. Preclinical development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Tumor suppressor activity of the TGF-beta pathway in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Role of Ras and Mapks in TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Farnesyltransferase inhibitor-induced regression of mammary tumors in TGF alpha and TGF alpha/neu transgenic mice correlates with inhibition of map kinase and p70s6 kinase phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

TGF-beta and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Isolation and characterization of Kirsten murine sarcoma virus-transformed mouse keratinocytes resistant to transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

The transforming growth factor-betas: past, present, and future

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Overexpression of transforming growth factor beta-type II receptor reduces tumorigenicity and metastastic potential of K-ras-transformed thyroid cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Interaction of transforming growth factor-beta receptor I with farnesyl-protein transferase-alpha in yeast and mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

TGF beta signals through a heteromeric protein kinase receptor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Characterization of human FAST-1, a TGF beta and activin signal transducer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

21 January 2018

Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

7 January 2021

based on heuristic

inferred from DOI database lookup

The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

7 January 2021

based on heuristic

inferred from DOI database lookup

Pre-clinical development of farnesyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein prenylation: a mediator of protein-protein interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

7 January 2021

based on heuristic

inferred from DOI database lookup

Cancer gets Mad: DPC4 and other TGFbeta pathway genes in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyltransferase inhibitors: targeting the molecular basis of cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

7 January 2021

based on heuristic

inferred from DOI database lookup

Cross-talk between the Smad1 and Ras/MEK signaling pathways for TGFbeta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203920

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q40837781&oldid=1951534909"