Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis (Q40794530)

23 September 2017

Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis (English)

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23 September 2017

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Huo TI

1

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23 September 2017

Wang XW

2

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23 September 2017

Forgues M

3

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23 September 2017

Wu CG

4

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23 September 2017

Spillare EA

5

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23 September 2017

Giannini C

6

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23 September 2017

Brechot C

7

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23 September 2017

Harris CC

8

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23 September 2017

language of work or name

English

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publication date

1 June 2001

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23 September 2017

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23 September 2017

20

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23 September 2017

28

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23 September 2017

3620-3628

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204495

23 September 2017

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Expression of integrated hepatitis B virus X variants in human hepatocellular carcinomas and its significance

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

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Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

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Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis

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An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis

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Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappa B and induces nuclear translocation of transcription factor NF-kappa B proteins for transcriptional activation

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Mutational hot spot in the p53 gene in human hepatocellular carcinomas

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Trans-activation of HLA-DR gene by hepatitis B virus X gene product

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Hepatitis B virus X protein inhibits nucleotide excision repair

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Increasing evidence that hepatitis B virus X gene protein and p53 protein may interact in the pathogenesis of hepatocellular carcinoma

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HBx gene of hepatitis B virus induces liver cancer in transgenic mice

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X-gene product of hepatitis B virus induces apoptosis in liver cells

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T antigen is bound to a host protein in SY40-transformed cells

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Transcriptional repression of the human p53 gene by hepatitis B viral X protein

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p53, the cellular gatekeeper for growth and division

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

21 January 2018

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells

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Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts

21 January 2018

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p53-dependent cell cycle control: response to genotoxic stress

21 January 2018

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In vitro tumorigenicity of hepatitis B virus DNA and HBx protein

21 January 2018

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The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells

21 January 2018

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Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.

21 January 2018

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Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome

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Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis

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Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha

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Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinomas

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Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene

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EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins.

21 January 2018

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Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death

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p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro

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Functional inactivation but not structural mutation of p53 causes liver cancer.

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Genetic heterogeneity of hepatocellular carcinoma

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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p53 tumor-suppressor gene: clues to molecular carcinogenesis

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The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

21 January 2018

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Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3

21 January 2018

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Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein

21 January 2018

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Chemotherapeutic drug, adriamycin, restores the function of p53 protein in hepatitis B virus X (HBx) protein-expressing liver cells

21 January 2018

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Geographic variation of p53 mutational profile in nonmalignant human liver

21 January 2018

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7 January 2021

Hepatitis B virus X protein interferes with cellular DNA repair.

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7 January 2021

HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX

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7 January 2021

Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta.

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7 January 2021

The timing of treatment in breast cancer: gaps and delays in treatment can be harmful.

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The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus

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7 January 2021

Hepatitis B and C viruses and hepatocellular carcinoma

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204495

7 January 2021

p53 status and the efficacy of cancer therapy in vivo

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7 January 2021

Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204495

7 January 2021

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204495

7 January 2021

Potential role of human cytomegalovirus and p53 interaction in coronary restenosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204495

7 January 2021

Overexpression of p53 protein is not directly related to hepatitis B x protein expression and is associated with neoplastic progression in hepatocellular carcinomas rather than hepatic preneoplasia.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204495

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

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7 January 2021

The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element.

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204495

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Dimensions Publication ID

23 September 2017

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