Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor (Q40792187)

23 September 2017

Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor (English)

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23 September 2017

Tse KF

1

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23 September 2017

Novelli E

2

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23 September 2017

Civin CI

3

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23 September 2017

Bohmer FD

4

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23 September 2017

Small D

5

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23 September 2017

1 July 2001

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23 September 2017

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23 September 2017

15

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23 September 2017

1001-1010

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23 September 2017

7

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2402199

23 September 2017

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Growth factor receptor tyrosine kinases

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STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells

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Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

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Receptor protein-tyrosine kinases and their signal transduction pathways

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Dimerization of cell surface receptors in signal transduction

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Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

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FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

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Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

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7 January 2021

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation.

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7 January 2021

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

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Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

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7 January 2021

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

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7 January 2021

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

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7 January 2021

The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

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7 January 2021

Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

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7 January 2021

Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan

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7 January 2021

Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

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7 January 2021

Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia

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7 January 2021

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

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Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

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7 January 2021

M-CSF and M-CSF-receptor gene expression in acute myelomonocytic leukemias

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7 January 2021

RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class

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7 January 2021

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

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7 January 2021

Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins

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7 January 2021

Epidermal-growth-factor-dependent activation of the src-family kinases

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7 January 2021

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

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7 January 2021

Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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7 January 2021

The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase

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7 January 2021

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

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7 January 2021

Expression of Flt3-ligand by the endothelial cell

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7 January 2021

In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

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7 January 2021

Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402199

7 January 2021

Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402199

7 January 2021

Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296.

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7 January 2021

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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7 January 2021

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

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7 January 2021

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402199

7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402199

7 January 2021

A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402199

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402199

1 reference

Dimensions Publication ID

23 September 2017

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