Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. (Q40756882)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11792712%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

title

Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1 (English)

1 reference

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6 December 2019

author

Christopher V. Carman

5

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6 December 2019

author name string

Qing Ma

1

1 reference

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6 December 2019

Motomu Shimaoka

2

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6 December 2019

Chafen Lu

3

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6 December 2019

Hua Jing

4

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6 December 2019

Timothy A Springer

6

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6 December 2019

language of work or name

English

0 references

publication date

15 January 2002

1 reference

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Journal of Biological Chemistry

6 December 2019

published in

1 reference

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6 December 2019

volume

277

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6 December 2019

issue

12

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6 December 2019

page(s)

10638-10641

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Structure and function of leukocyte integrins

6 December 2019

cites work

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T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

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Regulation of leukocyte integrin function: affinity vs. avidity

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21 January 2018

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An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

21 January 2018

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Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo

21 January 2018

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Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

21 January 2018

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Two conformations of the integrin A-domain (I-domain): a pathway for activation?

21 January 2018

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Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin

21 January 2018

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Structural basis of collagen recognition by integrin alpha2beta1

21 January 2018

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Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.

21 January 2018

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Computational design of an integrin I domain stabilized in the open high affinity conformation

21 January 2018

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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

21 January 2018

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An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

21 January 2018

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Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

21 January 2018

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The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

21 January 2018

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Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

21 January 2018

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NMR solution structure of the inserted domain of human leukocyte function associated antigen-1

21 January 2018

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A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1)

21 January 2018

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Divalent cation regulation of the function of the leukocyte integrin LFA-1

21 January 2018

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KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA-1- and CR3-dependent adhesion

21 January 2018

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Distinct binding of T lymphocytes to ICAM-1, -2 or -3 upon activation of LFA-1.

21 January 2018

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Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

21 January 2018

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Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M112417200

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