Anti-(Raf-1) RNA aptamers that inhibit Ras-induced Raf-1 activation. (Q40749465)

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7 December 2019

title

Anti-(Raf-1) RNA aptamers that inhibit Ras-induced Raf-1 activation (English)

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7 December 2019

4

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7 December 2019

Shigeyuki Yokoyama

7

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7 December 2019

author name string

Michiko Kimoto

1

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7 December 2019

Mikako Shirouzu

2

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7 December 2019

Shin Mizutani

3

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7 December 2019

Yoshito Kaziro

5

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7 December 2019

Ichiro Hirao

6

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7 December 2019

language of work or name

English

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publication date

1 January 2002

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7 December 2019

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7 December 2019

volume

269

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7 December 2019

page(s)

697-704

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7 December 2019

issue

2

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

7 December 2019

cites work

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raf family serine/threonine protein kinases in mitogen signal transduction.

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Increasing complexity of Ras signaling.

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

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Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

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Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

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The ins and outs of Raf kinases

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Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

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Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

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ralGDS family members interact with the effector loop of ras p21.

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

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Selection of phage-displayed fab antibodies on the active conformation of ras yields a high affinity conformation-specific antibody preventing the binding of c-Raf kinase to Ras.

21 January 2018

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Paradoxical activation of Raf by a novel Raf inhibitor

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In vitro selection of RNA molecules that bind specific ligands

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Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

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Controlling gene expression in living cells through small molecule-RNA interactions.

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Nucleic acid aptamers-from selection in vitro to applications in vivo

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Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers

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Cytoplasmic RNA modulators of an inside-out signal-transduction cascade

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RNA aptamers as effective protein antagonists in a multicellular organism

21 January 2018

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Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS

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Ras-interacting domain of RGL blocks Ras-dependent signal transduction in Xenopus oocytes.

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GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.

21 January 2018

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Isolation of a new protein factor required for activation of Raf-1 by Ha-Ras: partial purification from rat brain cytosols

21 January 2018

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Formation of the Ras dimer is essential for Raf-1 activation

21 January 2018

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Solution structure of the Ras-binding domain of RGL

21 January 2018

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Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

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17 Predicting optimal and suboptimal secondary structure for RNA

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Double-Mutant Analysis of the Interaction of Ras with the Ras-Binding Domain of RGL†

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Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

21 January 2018

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Selective targeting and inhibition of yeast RNA polymerase II by RNA aptamers

21 January 2018

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RNA aptamers that specifically bind to the Ras-binding domain of Raf-1

21 January 2018

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RNA aptamers that bind to and inhibit the ribosome-inactivating protein, pepocin

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Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo

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