A novel role for Gq alpha in alpha-thrombin-mediated mitogenic signalling pathways (Q40744295)

23 September 2017

A novel role for Gq alpha in alpha-thrombin-mediated mitogenic signalling pathways (English)

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23 September 2017

Alice Gardner

1

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23 September 2017

Polly J Phillips-Mason

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2

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23 September 2017

Daniel M Raben

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3

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23 September 2017

Joseph J Baldassare

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4

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23 September 2017

1 June 2002

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23 September 2017

9

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inferred from page(s)

published in

Cellular Signalling

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23 September 2017

14

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23 September 2017

6

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23 September 2017

499-507

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Alpha-thrombin receptors and growth signaling

23 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

How the protease thrombin talks to cells

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Role of the thrombin receptor in development and evidence for a second receptor.

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain.

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Thrombin receptor structure and function

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Modulation of thrombin-stimulated lipid responses in cultured fibroblasts. Evidence for two coupling mechanisms

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Suppression of phospholipase C beta, gamma, and delta families alters cell growth and phosphatidylinositol 4,5-bisphosphate levels

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors.

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of p44mapk and p42mapk isoforms in the G1 phase and their inactivation at the G1/S transition

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Evidence for a mammalian Nim1-like kinase pathway acting at the G0-1/S transition

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

D-type cyclin-dependent kinase activity in mammalian cells

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

1 reference

7 January 2021

Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Principles of CDK regulation

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Cyclin-dependent kinases: engines, clocks, and microprocessors

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Regulation of the cyclin E gene by transcription factor E2F1

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Ablation of Go alpha-subunit results in a transformed phenotype and constitutively active phosphatidylcholine-specific phospholipase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Thrombin and vascular smooth muscle cell proliferation: implications for atherosclerosis and restenosis

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

G12 requirement for thrombin-stimulated gene expression and DNA synthesis in 1321N1 astrocytoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Regulation of muscarinic acetylcholine receptor sequestration and function by beta-arrestin

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Expression of cell cycle-regulatory proteins rb, p16/MTS1, p27/KIP1, p21/WAF1, cyclin D1 and cyclin E in breast cancer: correlations with expression of activating protein-1 family members

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

Phosphatidylinositol 3-kinase activity regulates alpha -thrombin-stimulated G1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900279-0

7 January 2021

10.1016/S0898-6568(01)00279-0

Identifiers

DOI

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23 September 2017

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