Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2. (Q40700200)

22 September 2017

Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2. (English)

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22 September 2017

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Nathan H Lents

1

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22 September 2017

Susan M Keenan

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2

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22 September 2017

Clifford Bellone

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3

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22 September 2017

Joseph J Baldassare

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4

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22 September 2017

language of work or name

English

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publication date

30 September 2002

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

277

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22 September 2017

49

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22 September 2017

47469-47475

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https://api.crossref.org/works/10.1074%2FJBC.M207425200

22 September 2017

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G1 phase progression: cycling on cue

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M207425200

Cyclin-dependent regulation of G1 in mammalian fibroblasts.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M207425200

21 January 2018

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Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

21 January 2018

1 reference

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Regulation of the G1 phase of the mammalian cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

A Restriction Point for Control of Normal Animal Cell Proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Cell cycle: driving the centrosome cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Differential regulation of E2F transactivation by cyclin/cdk2 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Cdk2 associates with MAP kinase in vivo and its nuclear translocation is dependent on MAP kinase activation in IL-2-dependent Kit 225 T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Structural basis of cyclin-dependent kinase activation by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

The role of Cdk7 in CAK function, a retro-retrospective

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Regulation of CDK7 substrate specificity by MAT1 and TFIIH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase

21 January 2018

1 reference

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Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Raf-1 activates MAP kinase-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207425200

21 January 2018

Identifiers

DOI

10.1074/JBC.M207425200

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22 September 2017

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