Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins. (Q40692086)

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scientific article published on November 2002

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English	Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins.	scientific article published on November 2002

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scholarly article

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14 December 2019

Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins (English)

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14 December 2019

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Kenichi Mitsui

1

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14 December 2019

Hiroshi Nakayama

2

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14 December 2019

Takumi Akagi

3

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14 December 2019

Munenori Nekooki

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14 December 2019

Kenji Ohtawa

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14 December 2019

Koji Takio

6

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14 December 2019

Tsutomu Hashikawa

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14 December 2019

Nobuyuki Nukina

8

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14 December 2019

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1 November 2002

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14 December 2019

Journal of Neuroscience

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14 December 2019

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14 December 2019

9267-9277

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14 December 2019

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14 December 2019

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

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Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

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Glutamine repeats and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

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Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DMSO and glycerol reduce bacterial death induced by expression of truncated N-terminal huntingtin with expanded polyglutamine tracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extended polyglutamine selectively interacts with caspase-8 and -10 in nuclear aggregates

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elongation factor-1 alpha gene determines susceptibility to transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of an actin-binding protein from Dictyostelium as elongation factor 1a.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced levels of hsp90 compromise steroid receptor action in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat-shock protein hsp90 governs the activity of pp60v-src kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule severing by elongation factor 1 alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of the elongation factor-1alpha gene by p53 in association with death of an erythroleukemic cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-21-09267.2002

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14 December 2019

1 reference

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14 December 2019

1 reference

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14 December 2019

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