Adeno Associated Virus 9-Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice. (Q40644305)

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scientific article published on 18 July 2016

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English	Adeno Associated Virus 9-Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice.	scientific article published on 18 July 2016

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19 March 2020

Adeno Associated Virus 9-Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice (English)

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19 March 2020

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Soledad Bárez-López

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Ana Guadaño-Ferraz

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Hideyuki Iwayama

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Xiao-Hui Liao

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Lyndsey Braun

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Brian Kaspar

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Roy E Weiss

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Alexandra M Dumitrescu

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Samuel Refetoff

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23 August 2016

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1311-1319

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Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose-response study in mice and nonhuman primates

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Mutations of the thyroid hormone transporter MCT8 cause prenatal brain damage and persistent hypomyelination

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Changes in thyroid status during perinatal development of MCT8-deficient male mice

1 reference

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1 reference

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Distinct roles of deiodinases on the phenotype of Mct8 defect: a comparison of eight different mouse genotypes

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Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion

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Thyroid hormone-regulated mouse cerebral cortex genes are differentially dependent on the source of the hormone: a study in monocarboxylate transporter-8- and deiodinase-2-deficient mice.

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Evidence for a homodimeric structure of human monocarboxylate transporter 8.

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Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent

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Recombinant adeno-associated virus transduction and integration

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In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses

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Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene

1 reference

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Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation

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A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene

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Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter

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Myelination Delay and Allan-Herndon-Dudley Syndrome Caused by a Novel Mutation in the SLC16A2 Gene

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White matter abnormalities and dystonic motor disorder associated with mutations in the SLC16A2 gene

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Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

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20 August 2018

Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8.

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Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice

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Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle

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Identifiers

10.1089/THY.2016.0060

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19 March 2020

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19 March 2020

PubMed publication ID

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19 March 2020

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