Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment (Q40640593)

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scientific article published on 10 August 2015

Language	Label	Description	Also known as
English	Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment	scientific article published on 10 August 2015

Statements

scholarly article

1 reference

Europe PubMed Central

22 September 2017

Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment (English)

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Europe PubMed Central

22 September 2017

human embryonic stem cell

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based on heuristic

inferred from title

author name string

Mike Clements

1

1 reference

Europe PubMed Central

22 September 2017

Val Millar

2

1 reference

Europe PubMed Central

22 September 2017

Angela S Williams

3

1 reference

Europe PubMed Central

22 September 2017

Sian Kalinka

4

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Europe PubMed Central

22 September 2017

publication date

10 August 2015

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Europe PubMed Central

22 September 2017

Toxicological Sciences

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Europe PubMed Central

22 September 2017

148

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Europe PubMed Central

22 September 2017

1

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Europe PubMed Central

22 September 2017

241-260

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Europe PubMed Central

22 September 2017

Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Microfluidic heart on a chip for higher throughput pharmacological studies

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

CiPA: Ongoing testing, future qualification procedures, and pending issues

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

High-throughput multi-parameter profiling of electrophysiological drug effects in human embryonic stem cell derived cardiomyocytes using multi-electrode arrays.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

New easy-to-use hybrid system for extracellular potential and impedance recordings

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

1 reference

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21 January 2018

Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for I(Ks).

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Toward on-chip, in-cell recordings from cultured cardiomyocytes by arrays of gold mushroom-shaped microelectrodes

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Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model

1 reference

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21 January 2018

Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor γ-independent mitochondrial oxidative stress in mouse hearts

1 reference

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21 January 2018

Synthesis and evaluation of the permeability transition inhibitory characteristics of paramagnetic and diamagnetic amiodarone derivatives.

1 reference

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21 January 2018

On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip

1 reference

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21 January 2018

Electrophysiological safety of sibutramine HCl.

1 reference

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21 January 2018

MICE models: superior to the HERG model in predicting Torsade de Pointes

1 reference

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21 January 2018

Blockade of human HERG K⁺ channels by rosiglitazone, an antidiabetic drug.

1 reference

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21 January 2018

A new system for profiling drug-induced calcium signal perturbation in human embryonic stem cell-derived cardiomyocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Profiling of Nutrient Transporter Expression in Human Stem Cell-Derived Cardiomyocytes Exposed to Tyrosine Kinase Inhibitor Anticancer Drugs Using RBD Ligands

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity

1 reference

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21 January 2018

Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Mechanisms of zidovudine-induced mitochondrial toxicity and myopathy

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

The future of drug safety testing: expanding the view and narrowing the focus

1 reference

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21 January 2018

A multi-parameter in vitro screen in human stem cell-derived cardiomyocytes identifies ponatinib-induced structural and functional cardiac toxicity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil

1 reference

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21 January 2018

Dissolution and pharmacokinetics of a novel micronized aspirin formulation

1 reference

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21 January 2018

Microelectronic cell sensor assay for detection of cytotoxicity and prediction of acute toxicity

1 reference

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21 January 2018

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV180

21 January 2018

Identifiers

10.1093/TOXSCI/KFV180

1 reference

Europe PubMed Central

22 September 2017

release_2pyurdtbirhlzhip3txlnnbrou

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https://api.fatcat.wiki/v0/release/2pyurdtbirhlzhip3txlnnbrou

24 November 2022

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mapped directly with Wikidata item

1 reference

Europe PubMed Central

22 September 2017

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