Molecular pharmacology of somatostatin receptors (Q40601271)

21 September 2017

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title

Molecular pharmacology of somatostatin receptors (English)

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21 September 2017

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D Hoyer

1

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author name string

H Lübbert

series ordinal

2

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PubMed ID

7870182

21 September 2017

C Bruns

series ordinal

3

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21 September 2017

1 November 1994

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Naunyn-Schmiedeberg's Archives of Pharmacology

21 September 2017

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21 September 2017

350

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21 September 2017

5

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21 September 2017

441-453

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https://scigraph.springernature.com/pub.10.1007/bf00173012

21 September 2017

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cites work

The two isoforms of the mouse somatostatin receptor (mSSTR2A and mSSTR2B) differ in coupling efficiency to adenylate cyclase and in agonist-induced receptor desensitization

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12 December 2020

Somatostatin release from cerebral cortical cells: influence of amino acid neurotransmitters

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12 December 2020

Pharmacological evidence that somatostatin activates the m-current in hippocampal pyramidal neurons.

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12 December 2020

High affinity binding sites for somatostatin to rat pituitary

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12 December 2020

Two types of somatostatin receptors differentiated by cyclic somatostatin analogs.

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12 December 2020

Effect of somatostatin on acetylcholine release from rat hippocampal synaptosomes

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12 December 2020

D-Trp8-somatostatin: An analog of somatostatin more potent than the native molecule

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12 December 2020

A proposed new nomenclature for 5-HT receptors.

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12 December 2020

Different ionic requirements for somatostatin receptor subpopulations in the brain.

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12 December 2020

A peptidase-resistant cyclic octapeptide analogue of somatostatin (SMS 201–995) modulates seizures induced by quinolinic and kainic acids differently in the rat hippocampus

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12 December 2020

Autoradiographic mapping of somatostatin receptors in the rat central nervous system and pituitary.

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12 December 2020

Somatostatin inhibits adrenergic and cholinergic neurotransmission in smooth muscle

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12 December 2020

Widespread reduction of somatostatin-like immunoreactivity in the cerebral cortex in Alzheimer's disease.

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12 December 2020

Specific high affinity binding sites for somatostatin-28 on pancreatic beta-cells: differences with brain somatostatin receptors

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12 December 2020

In vitro detection of somatostatin receptors in human tumors

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12 December 2020

Pertussis toxin treatment blocks the inhibition of somatostatin and increases the stimulation by forskolin of cyclic AMP accumulation and adrenocorticotropin secretion from mouse anterior pituitary tumor cells.

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12 December 2020

Pharmacological properties of the NMDA receptor involved in somatostatin release from cortical neurons.

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12 December 2020

Glutamate stimulates somatostatin release from diencephalic neurons in primary culture

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12 December 2020

Characterization of cloned somatostatin receptors SSTR4 and SSTR5.

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12 December 2020

Differential binding of somatostatin agonists to somatostatin receptors in brain and adenohypophysis

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12 December 2020

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

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12 December 2020

Preclinical and clinical studies with somatostatin related to the central nervous system

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12 December 2020

Expression cloning of a rat brain somatostatin receptor cDNA

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12 December 2020

Evidence that somatostatin enhances endogenous acetylcholine release in the rat hippocampus

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12 December 2020

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)

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12 December 2020

Somatostatin selectively inhibits noradrenaline release from hypothalamic neurones

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12 December 2020

Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.

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12 December 2020

SMS 201–995: A very potent and selective octapeptide analogue of somatostatin with prolonged action

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12 December 2020

Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides

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12 December 2020

Characterization of functional receptors for somatostatin in rat pituitary cells in culture

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12 December 2020

Characterization of somatostatin receptors in guinea-pig isolated ileum, vas deferens and right atrium

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12 December 2020

Beta-adrenergic and somatostatin receptors regulate Na-H exchange independent of cAMP.

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12 December 2020

Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP.

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12 December 2020

Somatostatin and cholecystokinin octapeptide differentially modulate the release of [3H]acetylcholine from caudate nucleus but not cerebral cortex: role of dopamine receptor activation.

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12 December 2020

Analogs of somatostatin selectively label distinct subtypes of somatostatin receptors in rat brain

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12 December 2020

Vasoactive intestinal polypeptide receptors linked to an adenylate cyclase, and their relationship with biogenic amine- and somatostatin-sensitive adenylate cyclases on central neuronal and glial cells in primary cultures

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12 December 2020

Somatostatin activates an inwardly rectifying K+ conductance in freshly dispersed rat somatotrophs

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12 December 2020

Pharmacological properties of two cloned somatostatin receptors

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12 December 2020

Somatostatin release is enhanced in the hippocampus of partially and fully kindled rats

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12 December 2020

Cellular mechanisms of somatostatin inhibition of calcium influx in the anterior pituitary cell line AtT-20

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12 December 2020

Neuropeptides and neuropathology in the amygdala in Alzheimer's disease: relationship between somatostatin, neuropeptide Y and subregional distribution of neuritic plaques

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12 December 2020

Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype

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12 December 2020

Cloning and expression of a rat somatostatin receptor enriched in brain

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12 December 2020

Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20

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12 December 2020

Expression patterns of rat somatostatin receptor genes in pre- and postnatal brain and pituitary

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12 December 2020

Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated GK protein in clonal rat anterior pituitary cell membranes

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12 December 2020

Subtypes of brain somatostatin receptors couple to multiple cellular effector systems

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12 December 2020

Purification of a pituitary receptor for somatostatin. The utility of biotinylated somatostatin analogs

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12 December 2020

Somatostatin augments the M-current in hippocampal neurons.

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12 December 2020

Somatostatin and muscarinic inhibition of canine enteric endocrine cells: cellular mechanisms

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12 December 2020

Somatostatin stimulates Ca2+-activated K+ channels through protein dephosphorylation

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12 December 2020

The anterior periventricular hypothalamus is the site of somatostatin inhibition of its own release: an in vitro and immunocytochemical study.

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12 December 2020

Somatostatin antagonist analog increases GH, insulin, and glucagon release in the rat

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12 December 2020

Somatostatin-14 and somatostatin-28 induce opposite effects on potassium currents in rat neocortical neurons

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12 December 2020

Cysteamine-induced depletion of central somatostatin-like immunoactivity: effects on behavior, learning, memory and brain neurochemistry

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12 December 2020

The somatostatin receptor in the GI tract

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12 December 2020

Different beta-subunits determine G-protein interaction with transmembrane receptors

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12 December 2020

Cloning and characterization of a fourth human somatostatin receptor

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12 December 2020

A potent cyclic hexapeptide analogue of somatostatin

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12 December 2020

The somatostatin receptor is directly coupled to adenylate cyclase in GH4C1 pituitary cell membranes.

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12 December 2020

Agonist binding to rat brain somatostatin receptors alters the interaction of the receptors with guanine nucleotide-binding regulatory proteins.

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12 December 2020

Somatostatin cyclic octapeptide analogs which preferentially bind to SOMa receptors block a calcium current in rat superior cervical ganglion neurons

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12 December 2020

The use of the long-acting somatostatin analogue, octreotide acetate, in patients with islet cell tumors

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12 December 2020

Brain somatostatin receptor subpopulation visualized by autoradiography

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12 December 2020

Somatostatin Analogs Inhibit Somatostatin Release*

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12 December 2020

The inhibitory effect of somatostatin peptides on the rat anococcygeus muscle in vitro

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12 December 2020

Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase

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12 December 2020

New specific radioligand for one subpopulation of brain somatostatin receptors.

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12 December 2020

Cloning and expression of a novel mouse somatostatin receptor (SSTR2B).

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12 December 2020

The rat SSTR2 somatostatin receptor subtype is coupled to inhibition of cyclic AMP accumulation

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12 December 2020

Somatostatin mediation of adenohypophysial secretion

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12 December 2020

Highly active cyclic and bicyclic somatostatin analogues of reduced ring size

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12 December 2020

Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain

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12 December 2020

Somatostatin receptors on pituitary somatotrophs, thyrotrophs, and lactotrophs: pharmacological evidence for loose coupling to adenylate cyclase

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12 December 2020

Somatostatin induces an inward rectification in rat locus coeruleus neurones through a pertussis toxin-sensitive mechanism

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12 December 2020

CSF somatostatin in obsessive-compulsive disorder.

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12 December 2020

Somatostatin in the central nervous system: physiology and pathological modifications

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12 December 2020

Decreased somatostatin immunoreactivity but not neuropeptide Y immunoreactivity in cerebral cortex in senile dementia of Alzheimer type.

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12 December 2020

Differential effects of somatostatin on adenylate cyclase as functional correlate for different brain somatostatin receptor subpopulations

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12 December 2020

Calcitonin gene-related peptide stimulates rat gastric somatostatin release in vitro

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12 December 2020

Transient expression of somatostatin receptors in the rat cerebellum during development

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12 December 2020

The Role of Somatostatin and Its Analogs in the Diagnosis and Treatment of Tumors

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12 December 2020

Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors.

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12 December 2020

Extracellular somatostatin measured by microdialysis in the hippocampus of freely moving rats: evidence for neuronal release

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12 December 2020

Molecular biology of somatostatin receptors

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12 December 2020

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12 December 2020

Somatostatin in Alzheimer's disease and depression

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12 December 2020

Cysteamine-induced depletion of somatostatin produces differential cognitive deficits in rats.

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12 December 2020

Effects of somatostatin on the secretion of thyrotropin and prolactin

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12 December 2020

Somatostatin receptors: identification and characterization in rat brain membranes

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12 December 2020

Identification and characterization of somatostatin receptors in neonatal rat long bones

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12 December 2020

Somatostatin receptors: distribution in rat central nervous system and human frontal cortex.

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12 December 2020

Somatostatin analogs. Dissociation of brain receptor binding affinities and pituitary actions in the rat

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12 December 2020

Antagonist effects of seglitide (MK 678) at somatostatin receptors in guinea-pig isolated right atria

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12 December 2020

Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.

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12 December 2020

Long-lasting antinociceptive effect of RC-160, a somatostatin analog, in mice and rats

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12 December 2020

Definition of pharmacological receptors

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12 December 2020

Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4

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12 December 2020

Functional somatostatin receptors on a rat pancreatic acinar cell line

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12 December 2020

Differential distribution of somatostatin receptor subtypes in rat brain revealed by newly developed somatostatin analogs

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12 December 2020

Somatostatin inhibits basal and vasoactive intestinal peptide-stimulated hormone release by different mechanisms in GH pituitary cells

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12 December 2020

Molecular cloning and functional expression of a brain-specific somatostatin receptor

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12 December 2020

Receptor binding of somatostatin-28 is tissue specific

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12 December 2020

Somatostatin regulates dopamine release in rat striatal slices and cat caudate nuclei

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12 December 2020

Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain

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12 December 2020

Localization and characterization of brain somatostatin receptors as studied with somatostatin-14 and somatostatin-28 receptor radioautography.

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12 December 2020

Somatostatin facilitates the serotonin release from rat cerebral cortex, hippocampus and hypothalamus slices

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12 December 2020

Lack of cross-desensitization of somatostatin-14 and somatostatin-28 receptors coupled to potassium channels in rat neocortical neurons.

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12 December 2020

Somatostatin receptors in the nucleus accumbens selectively mediate the stimulatory effect of somatostatin on locomotor activity in rats.

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12 December 2020

Somatostatin and Analogues in the Treatment of Cancer

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12 December 2020

Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase

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12 December 2020

Somatostatin activates glibenclamide-sensitive and ATP-regulated K+ channels in insulinoma cells via a G-protein

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12 December 2020

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney

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12 December 2020

Somatostatin receptor subtypes in the clonal anterior pituitary cell lines AtT-20 and GH3.

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12 December 2020

Synthesis and biological activity of highly potent octapeptide analogs of somatostatin

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12 December 2020

Reduced density of striatal somatostatin receptors in Huntington's chorea

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12 December 2020

Huntington's disease is accompanied by changes in the distribution of somatostatin-containing neuronal processes

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12 December 2020

Autoradiographic localization of a non-reducible somatostatin analog (125I-CGP 23996) binding sites in the rat brain: comparison with membrane binding.

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12 December 2020

An analysis of the negative inotropic action of somatostatin

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12 December 2020

Somatostatin receptor binding in rat cerebral cortex. Characterization using a nonreducible somatostatin analog

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12 December 2020

In vitro release of somatostatin from cerebral cortical slices: characterization of electrically evoked release.

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12 December 2020

A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line

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12 December 2020

Differential expression of messenger RNAs for somatostatin receptor subtypes SSTR1, SSTR2 and SSTR3 in adult rat brain: analysis by RNA blotting and in situ hybridization histochemistry.

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12 December 2020

Somatostatin receptors on rat pancreatic acinar cells. Pharmacological and structural characterization and demonstration of down-regulation in streptozotocin diabetes

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12 December 2020

A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells

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12 December 2020

Tissue distribution of somatostatin receptor subtype messenger ribonucleic acid in the rat

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12 December 2020

Somatostatin increases an inwardly rectifying potassium conductance in guinea-pig submucous plexus neurones

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12 December 2020

Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line

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12 December 2020

The effects of cysteamine on dopamine-mediated behaviors: evidence for dopamine-somatostatin interactions in the striatum.

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12 December 2020

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

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12 December 2020

Use of the mouse vas deferens assay to evaluate the action of somatostatin peptides on gastric acid secretion

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12 December 2020

Localization of somatostatin (SRIF) SSTR-1, SSTR-2 and SSTR-3 receptor mRNA in rat brain by in situ hybridization.

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12 December 2020

Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms

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12 December 2020

Distinct topographical localisation of two somatostatin receptor subpopulations in the human cortex

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12 December 2020

Splice variant of the somatostatin receptor 2 subtype, somatostatin receptor 2B, couples to adenylyl cyclase

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12 December 2020

Parallel in vivo and in vitro detection of functional somatostatin receptors in human endocrine pancreatic tumors: consequences with regard to diagnosis, localization, and therapy

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12 December 2020

A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides

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12 December 2020

Calcium-dependent release of somatostatin and neurotensin from rat brain in vitro

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12 December 2020

Gi alpha 3 and G(o) alpha selectively associate with the cloned somatostatin receptor subtype SSTR2

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12 December 2020

Somatostatin inhibition of hippocampal CA1 pyramidal neurons: mediation by arachidonic acid and its metabolites.

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12 December 2020

Evidence for two somatostatin-14 receptor types in rat brain cortex

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12 December 2020

All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase

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12 December 2020

Distribution of somatostatin receptors in the human brain: an autoradiographic study

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12 December 2020

Effects of somatostatin-14 on the in vitro release of [3H]GABA from slices of rat caudatoputamen

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12 December 2020

Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28

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12 December 2020

Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins

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12 December 2020

Identifiers

DOI

10.1007/BF00173012

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21 September 2017

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PubMed ID

7870182