Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients. (Q40582287)

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4 November 2019

title

Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients (English)

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Nijmegen breakage syndrome

4 November 2019

main subject

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2

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4 November 2019

Krystyna Chrzanowska

series ordinal

3

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4 November 2019

4

Göran Roos

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4 November 2019

1

Jan Konrad Siwicki

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4 November 2019

language of work or name

English

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publication date

1 July 2003

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Experimental Cell Research

4 November 2019

published in

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4 November 2019

volume

287

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4 November 2019

issue

1

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4 November 2019

page(s)

178-189

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Eleven Polish patients with microcephaly, immunodeficiency, and chromosomal instability: the Nijmegen breakage syndrome.

4 November 2019

cites work

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Genetic mapping using microcell-mediated chromosome transfer suggests a locus for Nijmegen breakage syndrome at chromosome 8q21-24.

7 January 2021

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Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

7 January 2021

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The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

7 January 2021

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hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

7 January 2021

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The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response

7 January 2021

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NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

7 January 2021

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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

7 January 2021

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Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

7 January 2021

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Nijmegen breakage syndrome: consequences of defective DNA double strand break repair

7 January 2021

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The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

7 January 2021

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

7 January 2021

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Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

7 January 2021

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An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

7 January 2021

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Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

7 January 2021

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Reconsideration of senescence, immortalization and telomere maintenance of Epstein-Barr virus-transformed human B-lymphoblastoid cell lines

7 January 2021

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Long-term growth of human WGA-activated T-lymphocytes without feeder cells

7 January 2021

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Long-term cultured IL-2-dependent T cell lines demonstrate p16(INK4a) overexpression, normal pRb/p53, and upregulation of cyclins E or D2.

7 January 2021

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A Detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis

7 January 2021

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A role for both RB and p53 in the regulation of human cellular senescence

7 January 2021

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Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

7 January 2021

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Mechanism of telomerase induction during T cell activation

7 January 2021

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Changes in telomerase activity and telomere length during human T lymphocyte senescence

7 January 2021

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Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

7 January 2021

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

7 January 2021

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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

7 January 2021

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Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase

7 January 2021

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Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential.

7 January 2021

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Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization

7 January 2021

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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

7 January 2021

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Loss of functional pRB is not a ubiquitous feature of B-cell malignancies

7 January 2021

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Ovarian cancer cells that coexpress endogenous Rb and p16 are insensitive to overexpression of functional p16 protein

7 January 2021

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Cyclin E, a redundant cyclin in breast cancer

7 January 2021

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Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation

7 January 2021

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New link in a web of human genes

7 January 2021

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Direct activation of TERT transcription by c-MYC.

7 January 2021

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Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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10.1016/S0014-4827(03)00140-X

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12799193%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference