Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling (Q40582216)

21 September 2017

Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling (English)

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21 September 2017

Hua Zhang

1

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21 September 2017

Wei Wu

2

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21 September 2017

Yan Du

3

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21 September 2017

Sarah J Santos

4

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21 September 2017

Susan E Conrad

5

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21 September 2017

Jack T Watson

6

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21 September 2017

Nicholas Grammatikakis

7

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21 September 2017

Kathleen A Gallo

8

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21 September 2017

language of work or name

English

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publication date

4 March 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

19

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21 September 2017

19457-19463

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Mixed-lineage kinase control of JNK and p38 MAPK pathways

21 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Identification and characterization of a novel MAP kinase kinase kinase, MLTK

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Regulation of endogenous gene expression with a small-molecule dimerizer

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Physical interaction of mammalian CDC37 with CDK4

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311377200

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Mutational analysis of the tyrosine kinome in colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

Heat shock protein inhibitor shows antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311377200

21 January 2018

Identifiers

DOI

10.1074/JBC.M311377200

1 reference

21 September 2017

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