IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment. (Q40577440)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27520969%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment (English)

1 reference

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20 March 2020

7

1 reference

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20 March 2020

Teresa M McCabe

2

1 reference

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20 March 2020

Stefania Crotta

3

1 reference

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20 March 2020

Hans Henrik Gad

4

1 reference

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20 March 2020

Edith M Hessel

5

1 reference

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20 March 2020

Soren Beinke

6

1 reference

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20 March 2020

Andreas Wack

8

1 reference

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20 March 2020

author name string

Sophia Davidson

1

1 reference

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20 March 2020

publication date

1 September 2016

1 reference

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20 March 2020

published in

EMBO Molecular Medicine

1 reference

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20 March 2020

volume

8

1 reference

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20 March 2020

issue

9

1 reference

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20 March 2020

page(s)

1099-1112

1 reference

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Guarding the frontiers: the biology of type III interferons

20 March 2020

cites work

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IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.

22 September 2017

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NK cells require IL-28R for optimal in vivo activity

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies

22 September 2017

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Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection

22 September 2017

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Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

22 September 2017

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22 September 2017

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Macrophage-expressed IFN-β contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia

22 September 2017

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IFITM3 restricts the morbidity and mortality associated with influenza

22 September 2017

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Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival

22 September 2017

1 reference

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IFN-lambda determines the intestinal epithelial antiviral host defense

22 September 2017

1 reference

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Role of host immune response and viral load in the differential outcome of pandemic H1N1 (2009) influenza virus infection in Indian patients

22 September 2017

1 reference

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Type I interferon: friend or foe?

22 September 2017

1 reference

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Association of profoundly impaired immune competence in H1N1v-infected patients with a severe or fatal clinical course

22 September 2017

1 reference

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Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California.

22 September 2017

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Interplay between influenza A virus and the innate immune signaling

22 September 2017

1 reference

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IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells

22 September 2017

1 reference

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Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

22 September 2017

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Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets

22 September 2017

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Human interferon-lambda3 is a potent member of the type III interferon family.

22 September 2017

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The multifunctional NS1 protein of influenza A viruses

22 September 2017

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Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses

22 September 2017

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IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo

22 September 2017

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An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity

22 September 2017

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22 September 2017

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22 September 2017

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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

22 September 2017

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22 September 2017

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Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29)

22 September 2017

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Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

22 September 2017

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Neuraminidase inhibitors for preventing and treating influenza in healthy adults

22 September 2017

1 reference

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Re-emergence of fatal human influenza A subtype H5N1 disease

22 September 2017

1 reference

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IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

22 September 2017

1 reference

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IL-28, IL-29 and their class II cytokine receptor IL-28R

22 September 2017

1 reference

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Recent advances in the treatment of rhinovirus infections

22 September 2017

1 reference

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Sialic acid species as a determinant of the host range of influenza A viruses

22 September 2017

1 reference

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Enhanced virus resistance of transgenic mice expressing the human MxA protein.

22 September 2017

1 reference

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Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus

22 September 2017

1 reference

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The Use of Interferon-α in Virus Infections

22 September 2017

1 reference

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Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle

22 September 2017

1 reference

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Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses.

22 September 2017

1 reference

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Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells.

25 September 2017

1 reference

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IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease

25 September 2017

1 reference

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Emerging influenza antiviral resistance threats

15 June 2018

1 reference

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Polyclonal and monoclonal antibodies to the interferon-inducible protein Mx of influenza virus-resistant mice

15 June 2018

1 reference

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IFN-λ is able to augment TLR-mediated activation and subsequent function of primary human B cells.

15 June 2018

1 reference

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A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection

20 August 2018

1 reference

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Critical role of the endogenous interferon ligand-receptors in type I and type II interferons response.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5009813

Mx1 gene protects mice against the highly lethal human H5N1 influenza virus

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5009813

IL-29 and IFNα differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNγ receptor expression

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27520969

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IFN-λ-mediated IL-12 production in macrophages induces IFN-γ production in human NK cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27520969

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oromucosal interferon therapy: marked antiviral and antitumor activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27520969

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMMM.201606413

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27520969%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27520969%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference