The genes influencing the susceptibility to IDDM in humans (Q40575824)

21 September 2017

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title

The genes influencing the susceptibility to IDDM in humans (English)

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21 September 2017

S Faas

1

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PubMed ID

7829823

21 September 2017

M Trucco

series ordinal

2

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21 September 2017

1 July 1994

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Journal of Endocrinological Investigation

21 September 2017

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21 September 2017

17

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21 September 2017

7

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21 September 2017

477-495

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https://scigraph.springernature.com/pub.10.1007/bf03347743

21 September 2017

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T-cell antigen receptor genes and T-cell recognition

21 January 2018

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The significance of the concordance rate for type 1 (insulin-dependent) diabetes in identical twins.

21 January 2018

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21 January 2018

Map of the human MHC.

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The small subunit of HL-A antigens is beta 2-microglobulin

21 January 2018

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Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347743

HL-A antigens and diabetes mellitus.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347743

HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Oligonucleotide probes for HLA-DQA and DQB genes define susceptibility to type 1 (insulin-dependent) diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347743

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347743

A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347743

Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

A new HLA-DR2 extended haplotype is involved in insulin-dependent diabetes mellitus susceptibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

The amino acid at position 57 of the HLA-DQ beta chain and susceptibility to develop insulin-dependent diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Aspartic acid at position 57 of DQ beta chain does not protect against type 1 (insulin-dependent) diabetes mellitus in Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

High frequency of aspartic acid at position 57 of HLA-DQ beta-chain in Japanese IDDM patients and nondiabetic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Implication of specific DQB1 alleles in genetic susceptibility and resistance by identification of IDDM siblings with novel HLA-DQB1 allele and unusual DR2 and DR1 haplotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Incidence of type 1 (insulin-dependent) diabetes mellitus in subjects 0-14 years of age in the Comunidad of Madrid, Spain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

The X boxes from promoters of HLA class II B genes at different loci do not complete for nuclear protein-specific binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

The minimal number of class II MHC-antigen complexes needed for T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Polymorphism in the 5′ Flanking Region of the Human Insulin Gene: A Genetic Marker for Non-Insulin-Dependent Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Allelic variants of the human putative peptide transporter involved in antigen processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Genomic polymorphism, recombination, and linkage disequilibrium in human major histocompatibility complex-encoded antigen-processing genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

A tumour necrosis factor beta gene polymorphism in relation to monokine secretion and insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

TNF-alpha gene polymorphisms in type 1 (insulin-dependent) diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Mitochondrial diseases: genotype versus phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Diabetes mellitus in Kearns-Sayre syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Determinants of the selective toxicity of alloxan to the pancreatic B cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Early events in T-cell maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Somatic generation of antibody diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Rearrangement and expression of T cell antigen receptor and gamma genes during thymic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Positive selection of lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Negative selection of lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

The inability to process a self-peptide allows autoreactive T cells to escape tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

The staphylococcal enterotoxins and their relatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Islet-cell antibodies in juvenile diabetes mellitus of recent onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Usage of human T-cell receptor V beta, J beta, C beta, and V alpha gene segments is not proportional to gene number

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

To be or not to be Asp 57, that is the question

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Evidence for the effects of a superantigen in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Hybrid HLA-DC antigens provide molecular evidence for gene trans-complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347743

Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM

21 January 2018

1 reference

12 December 2020

Maternally inherited duplication of the mitochondrial genome in a syndrome of proximal tubulopathy, diabetes mellitus, and cerebellar ataxia

1 reference

12 December 2020

Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis

1 reference

12 December 2020

Polymorphic DNA region adjacent to the 5' end of the human insulin gene

1 reference

12 December 2020

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity

1 reference

12 December 2020

Polymorphism in the 5′-Flanking Region of the Human Insulin Gene and Its Possible Relation to Type 2 Diabetes

1 reference

12 December 2020

Non-HLA region genes in insulin dependent diabetes mellitus

1 reference

12 December 2020

Mechanisms of pancreatic beta-cell destruction in type I diabetes

1 reference

12 December 2020

Effect of vitamin E deficiency and selenium deficiency on insulin secretory reserve and free radical scavenging systems in islets: decrease of islet manganosuperoxide dismutase.

1 reference

12 December 2020

Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens

1 reference

12 December 2020

Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen

1 reference

12 December 2020

HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus

1 reference

12 December 2020

Childhood diabetes, epidemics, and epidemiology: an approach for controlling diabetes. World Health Organization DIAMOND Project Group on Epidemics

1 reference

12 December 2020

HLA-DR typing in identical twins with insulin-dependent diabetes: difference between concordant and discordant pairs

1 reference

12 December 2020

Rapid detection of IDDM susceptibility with HLA-DQ beta-alleles as markers

1 reference

12 December 2020

NcoI restriction fragment length polymorphism (RFLP) of the tumor necrosis factor (TNF alpha) region in four autoimmune diseases

1 reference

12 December 2020

Presentation of the Mls-1 superantigen by human HLA class II molecules to murine T cells.

1 reference

12 December 2020

Pearson bone marrow-pancreas syndrome with insulin-dependent diabetes, progressive renal tubulopathy, organic aciduria and elevated fetal haemoglobin caused by deletion and duplication of mitochondrial DNA

1 reference

12 December 2020

Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology

1 reference

12 December 2020

PCR-based analysis of the T-cell receptor V beta multigene family: experimental parameters affecting its validity

1 reference

12 December 2020

Insulin-gene sharing in sib pairs with insulin-dependent diabetes mellitus: no evidence for linkage

1 reference

12 December 2020

Transcomplementation of HLA genes in IDDM. HLA-DQ alpha- and beta-chains produce hybrid molecules in DR3/4 heterozygotes

1 reference

12 December 2020

HLA-DQ beta non-ASP-57 allele and incidence of diabetes in China and the USA

1 reference

12 December 2020

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1 reference

12 December 2020

The genetic susceptibility to type 1 (insulin-dependent) diabetes: analysis of the HLA-DR association

1 reference

12 December 2020

Interleukin-1 and interleukin-1 antagonism

1 reference

12 December 2020

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1 reference

12 December 2020

Structural and functional constraints on HLA class II dimers implicated in susceptibility to insulin dependent diabetes mellitus

1 reference

12 December 2020

Diabetes in identical twins. A study of 200 pairs

1 reference

12 December 2020

Congenital hypoplastic anemia, diabetes, and severe renal tubular dysfunction associated with a mitochondrial DNA deletion

1 reference

12 December 2020

Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

1 reference

12 December 2020

A Bovine Albumin Peptide as a Possible Trigger of Insulin-Dependent Diabetes Mellitus

1 reference

12 December 2020

Genetic susceptibility in diabetes mellitus: analysis of the HLA association

1 reference

12 December 2020

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

1 reference

12 December 2020

Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2

1 reference

12 December 2020

The T-cell receptor V beta gene usage in tumor-infiltrating lymphocytes and blood of patients with hepatocellular carcinoma

1 reference

12 December 2020

Restriction Fragment Length Polymorphism of the Insulin Gene in Diabetes Mellitus

1 reference

12 December 2020

Diabetes mellitus is one of the heterogeneous phenotypic features of a mitochondrial DNA point mutation within the tRNALeu(UUR) gene

1 reference

12 December 2020

Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11

1 reference

12 December 2020

Susceptibility to type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ alpha Arg 52 and HLA-DQ beta non-Asp 57 alleles

1 reference

12 December 2020

Autoimmunity and genetics contribute to the risk of insulin-dependent diabetes mellitus in families: islet cell antibodies and HLA DQ heterodimers

1 reference

12 December 2020

T cell receptor V beta gene expression in monozygotic twins. Discordance in CD8 subset and in disease states.

1 reference

12 December 2020

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion

1 reference

12 December 2020

Diabetes susceptibility in Sardinia

1 reference

12 December 2020

Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1

1 reference

12 December 2020

Protection from insulin-dependent diabetes mellitus is linked to a peptide transporter gene

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF03347743

1 reference

PubMed ID

7829823

Dimensions Publication ID

21 September 2017

0 references

1 reference

PubMed ID

7829823