The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation (Q40563497)

21 September 2017

The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation (English)

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21 September 2017

April N Meyer

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21 September 2017

Randy F Gastwirt

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2

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21 September 2017

David D Schlaepfer

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3

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21 September 2017

Daniel J Donoghue

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4

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21 September 2017

language of work or name

English

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publication date

22 April 2004

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Journal of Biological Chemistry

21 September 2017

8

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based on heuristic

inferred from page(s)

published in

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21 September 2017

279

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21 September 2017

28450-28457

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21 September 2017

27

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Signalling by receptor tyrosine kinases

21 September 2017

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FGFs, heparan sulfate and FGFRs: complex interactions essential for development

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RTK mutations and human syndromeswhen good receptors turn bad.

21 January 2018

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Signal transduction by receptors with tyrosine kinase activity

21 January 2018

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The ins and outs of fibroblast growth factors

21 January 2018

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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

21 January 2018

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Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1)

21 January 2018

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Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.

21 January 2018

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Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

21 January 2018

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Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain

21 January 2018

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Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

21 January 2018

1 reference

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Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily

21 January 2018

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A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

21 January 2018

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Protection from natural killer cell-mediated lysis by HLA-G expression on target cells

21 January 2018

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Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase

21 January 2018

1 reference

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RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes

21 January 2018

1 reference

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Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor

21 January 2018

1 reference

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RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells.

21 January 2018

1 reference

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SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells

21 January 2018

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Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation

21 January 2018

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Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

21 January 2018

1 reference

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Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

21 January 2018

1 reference

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Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II

21 January 2018

1 reference

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Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain

21 January 2018

1 reference

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Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras

21 January 2018

1 reference

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Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

21 January 2018

1 reference

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A functional DNA binding domain is required for growth hormone-induced nuclear accumulation of Stat5B.

21 January 2018

1 reference

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High-efficiency transformation of mammalian cells by plasmid DNA

21 January 2018

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Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma

21 January 2018

1 reference

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Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen-activated protein kinase activation

21 January 2018

1 reference

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Dissecting the catalytic mechanism of protein-tyrosine phosphatases

21 January 2018

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Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

21 January 2018

1 reference

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Chimeras of the native form or achondroplasia mutant (G375C) of human fibroblast growth factor receptor 3 induce ligand-dependent differentiation of PC12 cells

21 January 2018

1 reference

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Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations

21 January 2018

1 reference

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Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

21 January 2018

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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

21 January 2018

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FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

21 January 2018

1 reference

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

21 January 2018

1 reference

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

1 reference

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

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Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity

21 January 2018

1 reference

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Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.

21 January 2018

1 reference

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Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

21 January 2018

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Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9

21 January 2018

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Constitutively active STAT5 variants induce growth and survival of hematopoietic cells through a PI 3-kinase/Akt dependent pathway.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M403335200

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21 September 2017

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