Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions. (Q40523198)

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4 January 2020

title

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions (English)

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6

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4 January 2020

Martin J Stoermer

series ordinal

3

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4 January 2020

Joel D. A. Tyndall

series ordinal

5

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4 January 2020

Paul R Young

series ordinal

7

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1

Keith J Chappell

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2

Tessa A Nall

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4

Ning-Xia Fang

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language of work or name

English

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publication date

19 October 2004

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Journal of Biological Chemistry

4 January 2020

published in

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volume

280

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4 January 2020

page(s)

2896-2903

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issue

4

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The molecular biology of West Nile Virus: a new invader of the western hemisphere

4 January 2020

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The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

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Serological evidence of West Nile virus, Usutu virus and Sindbis virus infection of birds in the UK.

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Efficacy of killed virus vaccine, live attenuated chimeric virus vaccine, and passive immunization for prevention of West Nile virus encephalitis in hamster model

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Flavivirus premembrane protein cleavage and spike heterodimer secretion require the function of the viral proteinase NS3.

21 January 2018

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Mutagenesis of conserved residues at the yellow fever virus 3/4A and 4B/5 dibasic cleavage sites: effects on cleavage efficiency and polyprotein processing

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Mutagenesis of the yellow fever virus NS2A/2B cleavage site: effects on proteolytic processing, viral replication, and evidence for alternative processing of the NS2A protein

21 January 2018

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The carboxy-terminal part of the NS 3 protein of the West Nile Flavivirus can be isolated as a soluble protein after proteolytic cleavage and represents an RNA-stimulated NTPase

21 January 2018

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Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors.

21 January 2018

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Cotranslational membrane insertion of the serine proteinase precursor NS2B-NS3(Pro) of dengue virus type 2 is required for efficient in vitro processing and is mediated through the hydrophobic regions of NS2B.

21 January 2018

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Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.

21 January 2018

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The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor.

21 January 2018

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Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects

21 January 2018

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Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease

21 January 2018

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Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

21 January 2018

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Crystal structure of Dengue virus NS3 protease in complex with a Bowman-Birk inhibitor: implications for flaviviral polyprotein processing and drug design

21 January 2018

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Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin.

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All-atom models for the non-nucleoside binding site of HIV-1 reverse transcriptase complexed with inhibitors: a 3D QSAR approach

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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Comparison of the conformation and electrostatic surface properties of magainin peptides bound to sodium dodecyl sulfate and dodecylphosphocholine micelles

21 January 2018

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Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

21 January 2018

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Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

21 January 2018

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Protease inhibitors: current status and future prospects

21 January 2018

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21 January 2018

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N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M409931200

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15494419%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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