Overview of mutation assays in transgenic mice for routine testing (Q40517505)

21 September 2017

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title

Overview of mutation assays in transgenic mice for routine testing (English)

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21 September 2017

Gorelick NJ

1

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21 September 2017

1 January 1995

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Environmental and Molecular Mutagenesis

21 September 2017

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21 September 2017

25

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21 September 2017

3

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21 September 2017

218-230

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Correlation of carcinogenic potency with mouse-skin 32P-postlabeling and muta-Rmouse lac Z- mutation data for DMBA and its K-region sulphur isostere: comparison with activities observed in standard genotoxicity assays

21 September 2017

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

The use of shuttle vectors for mutation analysis in transgenic mice and rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

High somatic mutation frequencies in a LacZ transgene integrated on the mouse X-chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox Carcinogen Data Base. A report of the U.S. Environmental Protection Agency Gene-Tox Program

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

Transgenic systems for in vivo mutation analysis

21 January 2018

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https://api.crossref.org/works/10.1002%2FEM.2850250309

Intralaboratory optimization and standardization of mutant screening conditions used for a lambda/lacI transgenic mouse mutagenesis assay (I).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

Tissue-specific induction of mutations by streptozotocin in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

The lacI transgenic mouse mutagenicity assay: quantitative evaluation in comparison to tests for carcinogenicity and cytogenetic damage in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

Initial experiences and future directions for transgenic mouse mutation assays

21 January 2018

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https://api.crossref.org/works/10.1002%2FEM.2850250309

Response of the Muta mouse lacZ/galE- transgenic mutation assay to DMN: comparisons with the corresponding Big Blue (lacI) responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

Mutation studies with dimethyl nitrosamine in young and old lac I transgenic mice.

21 January 2018

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https://api.crossref.org/works/10.1002%2FEM.2850250309

Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

Phenobarbital: does the positive result in TA1535 indicate genotoxic properties?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Transgenic germ cell mutation assays: a small collaborative study

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https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Weak and unexpected mutagenicity to Salmonella of the rat hepatocarcinogen methapyrilene.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Mutagenicity of o-anisidine to the bladder of lacI- transgenic B6C3F1 mice: absence of 14C or 32P bladder DNA adduction.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Assessing the risk of heritable gene mutation in mammals: drosophila sex-linked recessive lethal test and tests measuring DNA damage and repair in mammalian germ cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Chemical synthesis and detection of the cross-link 1-[N3-(2'-deoxycytidyl)]-2-[N1-(2'-deoxyguanosinyl)]ethane in DNA reacted with 1-(2-chloroethyl)-1-nitrosourea

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Statistical tests of significance in transgenic mutation assays: considerations on the experimental unit

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Statistical design and analysis of mutation studies in transgenic mice

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https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Software package for the management of sequencing projects using lacI transgenic animals

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

DBA/2 mice are as sensitive as SENCAR mice to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Overview of the workshops on statistical analysis of mutation data from transgenic mice

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https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Can nongenotoxic carcinogens be detected with the lacI transgenic mouse mutation assay?

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Detection of chemical mutagens using Muta Mouse: a transgenic mouse model

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vector

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Detection of opiate-enhanced increases in DNA damage, HPRT mutants, and the mutation frequency in human HUT-78 cells.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Evaluation of the genetic toxicity of the peroxisome proliferator and carcinogen methyl clofenapate, including assays using Muta Mouse and Big Blue transgenic mice.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Genomic position influences spontaneous mutagenesis of an integrated retroviral vector containing the hprt cDNA as target for mutagenesis

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Genome wide spontaneous mutation in human cells determined by the spectrum of mutations in hprt cDNA genes

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Induction of hepatic mutations in lacI transgenic mice.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Transgenic animal models for measuring mutations in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

A preliminary evaluation of the performance of the Muta Mouse (lacZ) and Big Blue (lacI) transgenic mouse mutation assays.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Validation studies with Muta™ mouse: A transgenic mouse model for detecting mutations in vivo

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https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Sources of variability in data from a lacI transgenic mouse mutation assay

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Study design and sample sizes for a lacI transgenic mouse mutation assay

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Determination of mutagenicity in tissues of transgenic mice following exposure to 1,3-butadiene and N-ethyl-N-nitrosourea

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Mutagenicity of peroxyacetyl nitrate (PAN) in vivo: tests for somatic mutations and chromosomal aberrations

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Mutations in liver DNA of lacI transgenic mice (Big Blue) following subchronic exposure to 2-acetylaminofluorene.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Molecular analysis of lacI mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Ras mutations in methylclofenapate-induced B6C3F1 and C57BL/10J mouse liver tumours.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

The concomitant detection of gene mutation and micronucleus induction by mitomycin C in vivo using lacZ transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Comparison of somatic mutation in a transgenic versus host locus

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Mutagenicity of methyl methanesulfonate (MMS) in vivo at the Dlb-1 native locus and a lacI transgene

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850250309

7 January 2021

Identifiers

DOI

10.1002/EM.2850250309

1 reference

21 September 2017

1 reference

PubMed ID

7737140