Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B. (Q40485786)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22279442%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B (English)

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21 January 2020

0 references

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coagulation factor IX

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5

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21 January 2020

Sushrusha Nayak

1

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21 January 2020

author name string

Debalina Sarkar

2

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21 January 2020

George Q Perrin

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21 January 2020

Babak Moghimi

4

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21 January 2020

Shangzhen Zhou

6

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21 January 2020

Barry J Byrne

7

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21 January 2020

Roland W Herzog

8

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21 January 2020

language of work or name

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7 December 2011

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Frontiers in Microbiology

21 January 2020

published in

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21 January 2020

volume

2

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21 January 2020

page(s)

244

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Capsid-specific T-cell responses to natural infections with adeno-associated viruses in humans differ from those of nonhuman primates

21 January 2020

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22 September 2017

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Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy

22 September 2017

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CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice

22 September 2017

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Role of regulatory T cells in tolerance to coagulation factors

22 September 2017

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Impact of the underlying mutation and the route of vector administration on immune responses to factor IX in gene therapy for hemophilia B.

22 September 2017

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Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome

22 September 2017

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Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy

22 September 2017

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Recombinant adeno-associated virus vectors induce functionally impaired transgene product-specific CD8+ T cells in mice

22 September 2017

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22 September 2017

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Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

22 September 2017

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Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts

22 September 2017

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Inhibitor development in haemophilia B: an orphan disease in need of attention

22 September 2017

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Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver.

22 September 2017

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Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

22 September 2017

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Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

22 September 2017

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Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver

22 September 2017

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Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1.

22 September 2017

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Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer

22 September 2017

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22 September 2017

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AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

22 September 2017

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22 September 2017

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15 June 2018

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15 June 2018

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15 June 2018

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15 June 2018

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Immune deviation by mucosal antigen administration suppresses gene-transfer-induced inhibitor formation to factor IX.

15 June 2018

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15 June 2018

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Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.

15 June 2018

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Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells.

15 June 2018

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High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

20 August 2018

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Induction of heme oxygenase-1 in factor VIII-deficient mice reduces the immune response to therapeutic factor VIII.

20 August 2018

1 reference

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Management of side effects of sirolimus therapy

20 August 2018

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The TSC-mTOR signaling pathway regulates the innate inflammatory response

20 August 2018

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20 August 2018

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Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells

20 August 2018

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Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance.

20 August 2018

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Major role of local immune responses in antibody formation to factor IX in AAV gene transfer

20 August 2018

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Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance

20 August 2018

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Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin

20 August 2018

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Muscle-directed gene transfer and transient immune suppression result in sustained partial correction of canine hemophilia B caused by a null mutation

20 August 2018

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Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.

20 August 2018

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20 August 2018

Identifiers

DOI

10.3389/FMICB.2011.00244

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22279442%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22279442%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

22279442

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22279442%20AND%20SRC:MED&resulttype=core&format=json