Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. (Q40448682)

20 September 2017

title

Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. (English)

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20 September 2017

5

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20 September 2017

H Wang

1

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20 September 2017

M Iezzi

2

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20 September 2017

S Theander

3

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20 September 2017

P A Antinozzi

4

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20 September 2017

P A Halban

6

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20 September 2017

C B Wollheim

7

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20 September 2017

publication date

9 March 2005

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20 September 2017

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20 September 2017

volume

48

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20 September 2017

issue

4

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20 September 2017

page(s)

720-731

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Role of clathrin in the regulated secretory pathway of pancreatic beta-cells

20 September 2017

cites work

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Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells

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Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes

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beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

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Attenuation of FGF signalling in mouse β-cells leads to diabetes

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Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

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Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene

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The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects

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12 December 2020

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

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12 December 2020

Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.

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12 December 2020

Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing

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12 December 2020

Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells

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12 December 2020

Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells

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12 December 2020

beta-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas.

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12 December 2020

Increased islet apoptosis in Pdx1+/- mice

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12 December 2020

Cx36 preferentially connects beta-cells within pancreatic islets

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12 December 2020

A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young

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12 December 2020

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

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12 December 2020

The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells

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12 December 2020

Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction

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12 December 2020

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

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12 December 2020

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion

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12 December 2020

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

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12 December 2020

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

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12 December 2020

Dorsal pancreas agenesis in N-cadherin- deficient mice

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12 December 2020

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

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12 December 2020

Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells

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12 December 2020

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

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12 December 2020

Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets

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12 December 2020

Disruption of IRS-2 causes type 2 diabetes in mice

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12 December 2020

Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism

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12 December 2020

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

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12 December 2020

IPF1, a homeodomain-containing transactivator of the insulin gene

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12 December 2020

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion

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12 December 2020

Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin

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12 December 2020

Regulatory factor linked to late-onset diabetes?

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12 December 2020

The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and is implicated in insulin exocytosis.

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12 December 2020

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

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12 December 2020

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

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12 December 2020

Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1

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12 December 2020

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

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12 December 2020

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

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12 December 2020

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

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12 December 2020

Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues

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12 December 2020

Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase

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12 December 2020

Pdx1 restores beta cell function in Irs2 knockout mice

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12 December 2020

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

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12 December 2020

Experimental models of transcription factor-associated maturity-onset diabetes of the young

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12 December 2020

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

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12 December 2020

Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors

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12 December 2020

Proinsulin processing in the rat insulinoma cell line INS after overexpression of the endoproteases PC2 or PC3 by recombinant adenovirus

1 reference

12 December 2020

Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion

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12 December 2020

Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis

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12 December 2020

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

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12 December 2020

The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells

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12 December 2020

Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

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12 December 2020

Neural cell adhesion molecule (N-CAM) is required for cell type segregation and normal ultrastructure in pancreatic islets

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12 December 2020

Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway

1 reference

12 December 2020

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.

1 reference

12 December 2020

Slow cleavage at the proinsulin B-chain/connecting peptide junction associated with low levels of endoprotease PC1/3 in transformed beta cells

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12 December 2020

Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells

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12 December 2020

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

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12 December 2020

The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene

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12 December 2020

Insulin-promoter-factor 1 is required for pancreas development in mice

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12 December 2020

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1 reference

12 December 2020

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

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12 December 2020

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein

1 reference

12 December 2020

Exendin-(9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: implications for basal intracellular cyclic adenosine 3',5'-monophosphate levels and beta-cell glucose competence

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12 December 2020

Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells

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12 December 2020

10.1007/S00125-005-1692-8

Identifiers

DOI

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20 September 2017

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