Reversal of different drug-resistant phenotypes by an autocatalytic multitarget multiribozyme directed against the transcripts of the ABC transporters MDR1/P-gp, MRP2, and BCRP. (Q40445903)

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English	Reversal of different drug-resistant phenotypes by an autocatalytic multitarget multiribozyme directed against the transcripts of the ABC transporters MDR1/P-gp, MRP2, and BCRP.	scientific article

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9 January 2020

Reversal of different drug-resistant phenotypes by an autocatalytic multitarget multiribozyme directed against the transcripts of the ABC transporters MDR1/P-gp, MRP2, and BCRP (English)

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9 January 2020

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9 January 2020

author name string

Petra Kowalski

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9 January 2020

Hermann Lage

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publication date

1 April 2005

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9 January 2020

Molecular Therapy

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9 January 2020

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508-522

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9 January 2020

Simple RNA enzymes with new and highly specific endoribonuclease activities

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Ribozyme structures and mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme

1 reference

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7 January 2021

Similar cleavage efficiencies of an oligoribonucleotide substrate and an mdr1 mRNA segment by a hammerhead ribozyme.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Selection and characterization of a high-activity ribozyme directed against the antineoplastic drug resistance-associated ABC transporter BCRP/MXR/ABCG2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Modulation of the atypical multidrug-resistant phenotype by a hammerhead ribozyme directed against the ABC transporter BCRP/MXR/ABCG2.

1 reference

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7 January 2021

Kinetic characterization of ribozymes directed against the cisplatin resistance-associated ABC transporter cMOAT/MRP2/ABCC2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells

1 reference

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7 January 2021

ABC-transporters: implications on drug resistance from microorganisms to human cancers

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

The reversal of multidrug resistance: an update

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

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Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

In vitro activity of minimised hammerhead ribozymes

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Modulation of multidrug resistance gene (mdr-1) with antisense oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

A novel, long-circulating, and functional liposomal formulation of antisense oligodeoxynucleotides targeted against MDR1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Construction of a novel artificial-ribozyme-releasing plasmid

1 reference

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7 January 2021

Construction of a novel RNA-transcript-trimming plasmid which can be used both in vitro in place of run-off and (G)-free transcriptions and in vivo as multi-sequences transcription vectors

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Multitarget ribozyme against the S1 genome segment of reovirus possesses novel cleavage activities and is more efficacious than its constituent mono-ribozymes.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolates

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Can hammerhead ribozymes be efficient tools to inactivate gene function?

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Selection of a high activity ribozyme against cytostatic drug resistance-associated glypican-3 using an in vitro assay containing total tumor RNA.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Glypican-3 is involved in cellular protection against mitoxantrone in gastric carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Decreased drug accumulation in a mitoxantrone-resistant gastric carcinoma cell line in the absence of P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Enhanced expression of human ABC-transporter tap is associated with cellular resistance to mitoxantrone

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Thermosensitivity of multidrug-resistant human gastric and pancreatic carcinoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Molecular analysis of therapy resistance in gastric cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.016

7 January 2021

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