Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective (Q40442266)

20 September 2017

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title

Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective (English)

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20 September 2017

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J P Murnane

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20 September 2017

1 March 1995

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Cancer and Metastasis Reviews

20 September 2017

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20 September 2017

14

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20 September 2017

17-29

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20 September 2017

1

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https://scigraph.springernature.com/pub.10.1007/bf00690208

20 September 2017

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cites work

Flow cytometric analysis of X-ray sensitivity in ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1007%2FBF00690208

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00690208

Radiation effects on DNA synthesis in a defined chromosomal replicon

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00690208

Caffeine potentiation of the lethal action of alkylating agents on L-cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00690208

G2 chromosomal radiosensitivity in ataxia telangiectasia lymphocytes.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00690208

Effect of aphidicolin on de novo DNA synthesis, DNA repair and cytotoxicity in gamma-irradiated human fibroblasts. Implications for the enhanced radiosensitivity in ataxia telangiectasia.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00690208

Restoration of radiation resistance in ataxia telangiectasia cells by the introduction of normal human chromosome 11.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00690208

Chromosome aberrations and radiation-induced cell death. II. Predicted and observed cell survival.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00690208

Cellular and molecular advances in elucidating p53 function

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00690208

p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines

21 January 2018

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12 December 2020

Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis

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12 December 2020

Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc.

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12 December 2020

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

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12 December 2020

Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts

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12 December 2020

Fission yeast wee1 protein kinase is not required for DMA damage-dependent mitotic arrest

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12 December 2020

T antigen is bound to a host protein in SY40-transformed cells

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12 December 2020

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

1 reference

12 December 2020

Establishment and characterization of a permanent pSV ori--transformed ataxia-telangiectasia cell line

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12 December 2020

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1 reference

12 December 2020

Transformation and radiosensitivity of human diploid skin fibroblasts transfected with activated ras oncogene and SV40 T-antigen

1 reference

12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

12 December 2020

Screening test for ataxia telangiectasia.

1 reference

12 December 2020

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

12 December 2020

p53 mutations increase resistance to ionizing radiation

1 reference

12 December 2020

Stable radioresistance in ataxia-telangiectasia cells containing DNA from normal human cells

1 reference

12 December 2020

Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages

1 reference

12 December 2020

G0 chromosomal radiosensitivity in ataxia telangiectasia lymphocytes.

1 reference

12 December 2020

Differential effect of ionizing radiation on the expression of cyclin A and cyclin B in HeLa cells

1 reference

12 December 2020

Possible role for p34cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells

1 reference

12 December 2020

Responses of Synchronous Populations of HeLa Cells to Ultraviolet Irradiation at Selected Stages of the Generation Cycle

1 reference

12 December 2020

Comparison of gamma-radiation-induced accumulation of ataxia telangiectasia and control cells in G2 phase.

1 reference

12 December 2020

Reduction of radiation-induced cell cycle blocks by caffeine does not necessarily lead to increased cell killing

1 reference

12 December 2020

A critical look at the association of human genetic syndromes with sensitivity to ionizing radiation.

1 reference

12 December 2020

In vitro chromosomal radiosensitivity in "chromosomal breakage syndromes"

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12 December 2020

Effect of irradiation and theory of role of mitotic delay on the time course of labeling of HeLa S3 cells with tritiated thymidine.

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12 December 2020

Cancer in ataxia-telangiectasia

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12 December 2020

Caffeine-mediated release of alpha-radiation-induced G2 arrest increases the yield of chromosome aberrations

1 reference

12 December 2020

Evidence that x-irradiation inhibits DNA replicon initiation in Chinese hamster cells

1 reference

12 December 2020

Co-dominance of radioresistant DNA synthesis in a group of AT-like Chinese hamster cell mutants

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12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

12 December 2020

RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae

1 reference

12 December 2020

Variations in several responses of HeLa cells to x-irradiation during the division cycle

1 reference

12 December 2020

Deficient recovery from potentially lethal radiation damage in ataxia telangiectasia and xeroderma pigmentosum

1 reference

12 December 2020

The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40.

1 reference

12 December 2020

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

12 December 2020

A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis

1 reference

12 December 2020

Effects of caffeine on radiation-induced phenomena associated with cell-cycle traverse of mammalian cells

1 reference

12 December 2020

Cancer. p53, guardian of the genome

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12 December 2020

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1 reference

12 December 2020

Mitotic delay and chromosomal aberrations induced by X rays in synchronized Chinese hamster cells in vitro

1 reference

12 December 2020

Radiation-Induced Cellular Reproductive Death and Chromosome Aberrations

1 reference

12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

12 December 2020

WAF1, a potential mediator of p53 tumor suppression

1 reference

12 December 2020

Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks

1 reference

12 December 2020

The Effect of Caffeine on Radiation-induced Division Delay

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12 December 2020

Prolonged cell cycle delay in radioresistant human cell lines transfected with activated ras oncogene and/or simian virus 40 T-antigen.

1 reference

12 December 2020

ACTION OF RADIATION ON MAMMALIAN CELLS III. RELATIONSHIP BETWEEN REPRODUCTIVE DEATH AND INDUCTION OF CHROMOSOME ANOMALIES BY X-IRRADIATION OF EUPLOID HUMAN CELLS IN VITRO.

1 reference

12 December 2020

Radiation-induced potentially lethal damage: DNA lesions susceptible to fixation

1 reference

12 December 2020

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

1 reference

12 December 2020

Repair of Sub-lethal and Potentially Lethal Radiation Damage in Plateau Phase Cultures of Human Cells

1 reference

12 December 2020

Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage

1 reference

12 December 2020

The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae

1 reference

12 December 2020

E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts

1 reference

12 December 2020

Response of ataxia telangiectasia cells to restriction endonuclease induced DNA double-strand breaks: I. Cytogenetic characterization

1 reference

12 December 2020

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

12 December 2020

Abnormal response of ataxia-telangiectasia cells to agents that break the deoxyribose moiety of DNA via a targeted free radical mechanism.

1 reference

12 December 2020

Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint.

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12 December 2020

Use of the mitotic selection procedure for cell cycle analysis. Comparison between the X-ray and cycloheximide G2 markers

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12 December 2020

p53 mutations in human cancers

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12 December 2020

Radiation-Induced Division Delay in Synchronized Chinese Hamster Ovary Cells in Monolayer Culture

1 reference

12 December 2020

Effect of UV-irradiation on cell cycle, viability and the expression of p53, gadd153 and gadd45 genes in normal and HPV-immortalized human oral keratinocytes

1 reference

12 December 2020

Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after x-irradiation

1 reference

12 December 2020

A case of caffeine-mediated cancellation of mitotic delay without enhanced breakage in V79 cells

1 reference

12 December 2020

Enhanced radiosensitivity of cultured fibroblasts from ataxia telangiectasia heterozygotes manifested by defective colony-forming ability and reduced DNA repair replication after hypoxic gamma-irradiation

1 reference

12 December 2020

The effect of X irradiation on the progression of mouse 10T1/2 cells released from density-inhibited cultures

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12 December 2020

Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents

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12 December 2020

Effect of caffeine on DNA synthesis in irradiated and unirradiated mammalian cells

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12 December 2020

The cytogenetics of ataxia telangiectasia

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12 December 2020

Is chromatid-type damage in ataxia telangiectasia after irradiation at G0 a consequence of defective repair?

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12 December 2020

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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12 December 2020

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

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12 December 2020

The response of ataxia telangiectasia cells to bleomycin

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12 December 2020

Hybrid T cell receptor genes formed by interlocus recombination in normal and ataxia-telangiectasis lymphocytes

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12 December 2020

Unusual sensitivity of ataxia telangiectasia cells to bleomycin

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12 December 2020

On the nature of a defect in cells from individuals with ataxia-telangiectasia

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12 December 2020

Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells.

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12 December 2020

The rejoining of double-strand breaks in DNA by human cell extracts

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12 December 2020

A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts

1 reference

12 December 2020

Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity

1 reference

12 December 2020

Transrearrangements between antigen receptor genes in normal human lymphoid tissues and in ataxia telangiectasia

1 reference

12 December 2020

The Action of Caffeine on X-Irradiated HeLa Cells: III. Enhancement of X-Ray-Induced Killing during G 2 Arrest

1 reference

12 December 2020

Chromosome aberrations and radiation-induced cell death. I. Transmission and survival parameters of aberrations

1 reference

12 December 2020

Effects of X-irradiation on cell-cycle progression, induction of chromosomal aberrations and cell killing in ataxia telangiectasia (AT) fibroblasts

1 reference

12 December 2020

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage

1 reference

12 December 2020

Effects of caffeine on ultraviolet-irradiated mouse L cells

1 reference

12 December 2020

Transformation and radiosensitivity of human diploid skin fibroblasts transfected with SV40 T-antigen mutants defective in RB and P53 binding domains

1 reference

12 December 2020

Discerning the function of p53 by examining its molecular interactions

1 reference

12 December 2020

The Radiosensitivity of the Chromosomes of the Cells of Human Squamous Cell Carcinoma Cell Lines

1 reference

12 December 2020

Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes

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12 December 2020

Survey of radiosensitivity in a variety of human cell strains.

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12 December 2020

Effects of the DNA strand-cleaving antitumor agent, streptonigrin, on ataxia telangiectasia cells

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12 December 2020

Participation of p53 protein in the cellular response to DNA damage

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12 December 2020

Radiosensivity of mammalian cells. I. Timing and dose-dependence of radiation-induced division delay

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12 December 2020

Evidence for Dark-Reactivation of Ultraviolet Light Damage in Mouse L Cells

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12 December 2020

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

1 reference

12 December 2020

Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells

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12 December 2020

X-Ray-Induced Inhibition of DNA Synthesis in Chinese Hamster Ovary, Human HeLa, and Mouse L Cells

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12 December 2020

Loss of a yeast telomere: arrest, recovery, and chromosome loss.

1 reference

12 December 2020

Unusual levels of (ADP-ribose)n and DNA synthesis in ataxia telangiectasia cells following gamma-ray irradiation

1 reference

12 December 2020

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

1 reference

12 December 2020

The effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro

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12 December 2020

X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders

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12 December 2020

Complementation of the defects of DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells

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12 December 2020

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

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12 December 2020

Action of radiation on mammalian cells. IV. Reversible mitotic lag in the S3 HeLa cell produced by low doses of x-rays

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12 December 2020

In vitro X-ray sensitivity in ataxia telangiectasis homozygote and heterozygote skin fibroblasts under oxic and hypoxic conditions

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12 December 2020

The rate of DNA synthesis in normal human and ataxia telangiectasia cells after exposure to X-irradiation

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12 December 2020

Down-regulation of cell cycle control genes by ionizing radiation

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12 December 2020

Radiation effects on DNA chain growth in mammalian cells.

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12 December 2020

Cell checkpoint and radiosensitivity

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12 December 2020

Delayed Initiation of DNA Synthesis in Irradiated Human Diploid Cells

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12 December 2020

The action of caffeine on X-irradiated HeLa cells. I. Delayed inhibition of DNA synthesis

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12 December 2020

Effect of confluent holding on potentially lethal damage repair, cell cycle progression, and chromosomal aberrations in human normal and ataxia-telangiectasia fibroblasts

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12 December 2020

The structure of methylated xanthines in relation to their effects on DNA synthesis and cell lethality in nitrogen mustard-treated cells

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12 December 2020

Replication of chromosomal and episomal DNA in X-ray-damaged human cells: a cis- or trans-acting mechanism?

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12 December 2020

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization

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12 December 2020

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

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12 December 2020

Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.

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12 December 2020

Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells

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12 December 2020

High spontaneous intrachromosomal recombination rates in ataxia-telangiectasia

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12 December 2020

A death in the life of p53

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12 December 2020

Localization of inhibition of replicon initiation to damaged regions of DNA

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12 December 2020

Ultraviolet Irradiation of Mouse L Cells: Effects on DNA Synthesis and Progression through the Cell Cycle

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12 December 2020

Different drugs arrest cells at a number of distinct stages in G2.

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12 December 2020

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells

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12 December 2020

Radiosensitivity in ataxia-telangiectasia: a new explanation

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12 December 2020

Effects of ionizing radiation on DNA replication in cultured mammalian cells

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12 December 2020

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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12 December 2020

The use of integrating DNA vectors to analyse the molecular defects in ionising radiation-sensitive mutants of mammalian cells including ataxia telangiectasia

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12 December 2020

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

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12 December 2020

Mechanism by which caffeine potentiates lethality of nitrogen mustard

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12 December 2020

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

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12 December 2020

Mechanisms of inhibition of DNA replication by ultraviolet light in normal human and xeroderma pigmentosum fibroblasts

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12 December 2020

Radioresistant DNA synthesis: an intrinsic feature of ataxia telangiectasia

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12 December 2020

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

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12 December 2020

Inhibition of DNA replication factor RPA by p53.

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12 December 2020

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

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12 December 2020

X-ray--induced breakage and rejoining of human interphase chromosomes

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12 December 2020

Cellular hypersensitivity to neocarzinostatin in ataxia-telangiectasia skin fibroblasts

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12 December 2020

The transactivator proteins VP16 and GAL4 bind replication factor A.

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12 December 2020

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

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12 December 2020

Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice.

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12 December 2020

The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxia-telangiectasia

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12 December 2020

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant

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12 December 2020

Inhibition of DNA replication by ionizing radiation is mediated by a trans-acting factor

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12 December 2020

Molecular analysis of mutations in the hprt gene in circulating lymphocytes from normal and DNA-repair-deficient donors

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12 December 2020

The repair of potentially lethal damage in x-irradiated cultures of normal and ataxia telangiectasia human fibroblasts.

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12 December 2020

Recovery from ultraviolet-induced growth arrest of primary rat hepatocytes by p53 antisense oligonucleotide treatment

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12 December 2020

The molecular basis for cell cycle delays following ionizing radiation: a review

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12 December 2020

Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia

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12 December 2020

Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia

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12 December 2020

Identifiers

DOI

10.1007/BF00690208

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PubMed ID

7606817

Dimensions Publication ID

20 September 2017

0 references

1 reference

PubMed ID

7606817