Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice (Q40436889)

20 September 2017

Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice (English)

1 reference

20 September 2017

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5

Steven M Hersch

1 reference

20 September 2017

7

Robert J Ferrante

1 reference

20 September 2017

6

M Flint Beal

1 reference

20 September 2017

Alpaslan Dedeoglu

1

1 reference

20 September 2017

James K Kubilus

series ordinal

2

1 reference

20 September 2017

Lichuan Yang

series ordinal

3

1 reference

20 September 2017

Kimberly L Ferrante

series ordinal

4

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20 September 2017

language of work or name

English

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publication date

1 June 2003

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Journal of Neurochemistry

20 September 2017

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20 September 2017

85

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20 September 2017

1359-1367

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20 September 2017

6

1 reference

The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain

20 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease?

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Energetics in the pathogenesis of neurodegenerative diseases

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Is there a rationale for the use of creatine either as nutritional supplementation or drug administration in humans participating in a sport?

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Functional aspects of creatine kinase in brain.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Oxidative stress in Huntington's disease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Neuropathological classification of Huntington's disease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Therapeutic effects of cystamine in a murine model of Huntington's disease.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Direct antioxidant properties of creatine

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Lipoic acid improves survival in transgenic mouse models of Huntington's disease

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Huntington aggregates may not predict neuronal death in Huntington's disease

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Creatine and cyclocreatine attenuate MPTP neurotoxicity.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

3-Nitropropionic acid increases the intracellular Ca2+ in cultured astrocytes by reverse operation of the Na+-Ca2+ exchanger.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Mitochondrial defect in Huntington's disease caudate nucleus

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

The Blood–Brain Barrier Creatine Transporter is a Major Pathway for Supplying Creatine to the Brain

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866522

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

20 August 2018

1 reference

12 December 2020

Involvement of free radicals in excitotoxicity in vivo.

1 reference

12 December 2020

Preincubation with creatine enhances levels of creatine phosphate and prevents anoxic damage in rat hippocampal slices

1 reference

12 December 2020

Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo

1 reference

12 December 2020

Phosphocreatine-dependent Glutamate Uptake by Synaptic Vesicles

1 reference

12 December 2020

Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies

1 reference

12 December 2020

10.1046/J.1471-4159.2003.01706.X

Identifiers

DOI

1 reference

20 September 2017

1 reference

20 September 2017

1 reference