Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes (Q40433595)

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English	Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes	scientific article

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scholarly article

1 reference

Europe PubMed Central

20 September 2017

Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes (English)

1 reference

Europe PubMed Central

20 September 2017

object named as

Michael Kracht

12

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author name string

Axel Thiefes

1

1 reference

Europe PubMed Central

20 September 2017

Sabine Wolter

2

1 reference

Europe PubMed Central

20 September 2017

J Frederic Mushinski

3

1 reference

Europe PubMed Central

20 September 2017

Elke Hoffmann

4

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Europe PubMed Central

20 September 2017

Oliver Dittrich-Breiholz

5

1 reference

Europe PubMed Central

20 September 2017

Nadine Graue

6

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Europe PubMed Central

20 September 2017

Anneke Dörrie

7

1 reference

Europe PubMed Central

20 September 2017

Heike Schneider

8

1 reference

Europe PubMed Central

20 September 2017

Dagmar Wirth

9

1 reference

Europe PubMed Central

20 September 2017

Bruno Luckow

10

1 reference

Europe PubMed Central

20 September 2017

Klaus Resch

11

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Europe PubMed Central

20 September 2017

language of work or name

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publication date

18 April 2005

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Europe PubMed Central

20 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

20 September 2017

280

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Europe PubMed Central

20 September 2017

30

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Europe PubMed Central

20 September 2017

27728-27741

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Europe PubMed Central

20 September 2017

Transcriptional and post-transcriptional control of gene expression in inflammation

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21 January 2018

Proinflammatory cytokines

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21 January 2018

Toll-like receptor signalling

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21 January 2018

Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Crosstalk between NF-kappaB-activating and apoptosis-inducing proteins of the TNF-receptor complex

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https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Signal transduction by tumor necrosis factor and its relatives

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

New targets for anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

The Toll-IL-1 receptor adaptor family grows to five members.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Toll-like receptor signaling

1 reference

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21 January 2018

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

1 reference

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21 January 2018

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

1 reference

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21 January 2018

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

IRAK and TAK1 are required for IL-18-mediated signaling

1 reference

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21 January 2018

Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR

1 reference

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21 January 2018

Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

TAB3, a new binding partner of the protein kinase TAK1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

The NF-kappa b repressing factor is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-kappa b-flanking sequence element.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Identification of new regulatory sequences far upstream of the mouse monocyte chemoattractant protein-1 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding [...]

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Communication between NF-kappa B and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

New drugs for rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Protein kinases--the major drug targets of the twenty-first century?

1 reference

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21 January 2018

The IKK NF-kappa B system: a treasure trove for drug development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Feedback control of the protein kinase TAK1 by SAPK2a/p38

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Inhibition of JNK activation through NF-kappaB target genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

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21 January 2018

Identification of NF-kappa B-regulated genes induced by TNFalpha utilizing expression profiling and RNA interference

1 reference

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21 January 2018

Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells

1 reference

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21 January 2018

Distribution of NF-kappaB-binding sites across human chromosome 22

1 reference

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21 January 2018

Complexity of inflammatory responses in endothelial cells and vascular smooth muscle cells determined by microarray analysis.

1 reference

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21 January 2018

Computational prediction of transcription-factor binding site locations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411657200

21 January 2018

Identifying transcriptional targets

1 reference

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21 January 2018

Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition

1 reference

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21 January 2018

TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages

1 reference

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21 January 2018

Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice

1 reference

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21 January 2018

A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase

1 reference

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21 January 2018

Multiple signaling pathways regulate NF-kappaB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells

1 reference

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21 January 2018

Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M411657200

1 reference

Europe PubMed Central

20 September 2017

1 reference

Europe PubMed Central

20 September 2017

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