Neutrophilic inflammation in asthma: mechanisms and therapeutic considerations (Q40423635)

20 September 2017

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title

Neutrophilic inflammation in asthma: mechanisms and therapeutic considerations (English)

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20 September 2017

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So-My Koo

6

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author name string

Hun Soo Chang

1

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20 September 2017

Tae-Hyeong Lee

2

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20 September 2017

Ji Ae Jun

3

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20 September 2017

Ae Rin Baek

4

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20 September 2017

Jong-Sook Park

5

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20 September 2017

Yang-Ki Kim

7

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20 September 2017

Ho Sung Lee

8

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20 September 2017

Choon-Sik Park

9

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20 September 2017

language of work or name

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5 December 2016

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Expert Review of Respiratory Medicine

20 September 2017

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20 September 2017

11

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20 September 2017

1

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20 September 2017

29-40

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Non-eosinophilic cor ticosteroid unresponsive asthma

20 September 2017

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Occupational asthma due to low molecular weight agents: eosinophilic and non-eosinophilic variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Stability of inflammatory phenotypes in asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: A prospective study using multiple samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Effect of HFA-flunisolide on peripheral lung inflammation in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

The molecular mechanisms of glucocorticoids-mediated neutrophil survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

A large subgroup of mild-to-moderate asthma is persistently noneosinophilic

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Low sputum eosinophils predict the lack of response to beclomethasone in symptomatic asthmatic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Identification of subtypes of refractory asthma in Korean patients by cluster analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Role of neutrophils in persistent airway obstruction due to refractory asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Linkage between smoking and asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

The overlap syndrome of asthma and COPD: what are its features and how important is it?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Airway function and markers of airway inflammation in patients with treated hypothyroidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Endotoxin-stimulated innate immunity: A contributing factor for asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Dose-dependent cigarette smoking-related inflammatory responses in healthy adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Grain dust-induced airflow obstruction and inflammation of the lower respiratory tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Occupational exposures, smoking and airway inflammation in refractory asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Greater ozone-induced inflammatory responses in subjects with asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Long-term ambient ozone concentration and the incidence of asthma in nonsmoking adults: the AHSMOG Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

The effect of repeated exposure to particulate air pollution (PM10) on the bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Smoking and the outcome of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Respiratory viruses and exacerbations of asthma in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Barrier responses of human bronchial epithelial cells to grass pollen exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Facilitation of Allergic Sensitization and Allergic Airway Inflammation by Pollen-Induced Innate Neutrophil Recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Asthmatic airway neutrophilia after allergen challenge is associated with the glutathione S-transferase M1 genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Cluster analysis and clinical asthma phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Airway inflammation is augmented by obesity and fatty acids in asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Non-eosinophilic asthma: importance and possible mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Innate immune activation in neutrophilic asthma and bronchiectasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Diesel exhaust enhances virus- and poly(I:C)-induced Toll-like receptor 3 expression and signaling in respiratory epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

The role of Toll-like receptors and related receptors of the innate immune system in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Pathogenesis of severe asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Differences in airway cytokine profile in severe asthma compared to moderate asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

γδ T cells protect against lung fibrosis via IL-22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

IL-17-producing peripheral blood CD177+ neutrophils increase in allergic asthmatic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Interferon-gamma as a possible target in chronic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

The complex relationship between inflammation and lung function in severe asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

High IFN-γ and low SLPI mark severe asthma in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Inflammasome-IL-1-Th17 response in allergic lung inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Beyond pattern recognition: NOD-like receptors in dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB(1.).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Role of inflammasome activation in development and exacerbation of asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Elevation of S100 calcium binding protein A9 in sputum of neutrophilic inflammation in severe uncontrolled asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Neutrophil extracellular traps kill bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Identification of novel immune phenotypes for allergic and nonallergic childhood asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Increased matrix metalloproteinase-9 with elastolysis in nocturnal asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Air trapping is a major determinant of persistent airway obstruction in asthmatics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Differences in radiological/HRCT findings in eosinophilic bronchitis and asthma: implication for bronchial responsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Factors associated with persistent airflow limitation in severe asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Association between neutrophilic airway inflammation and airflow limitation in adults with asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Neutrophilic asthma has different radiographic features to COPD and smokers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Mepolizumab treatment in patients with severe eosinophilic asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Reslizumab for Poorly Controlled, Eosinophilic Asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Polymorphonuclear leukocyte inhibition by therapeutic concentrations of theophylline is mediated by cyclic-3',5'-adenosine monophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Formoterol attenuates neutrophilic airway inflammation in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Possible anti-inflammatory effect of salmeterol against interleukin-8 and neutrophil activation in asthma in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Clarithromycin targets neutrophilic airway inflammation in refractory asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Endothelium-dependent effects of statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Simvastatin enhances the regeneration of endothelial cells via VEGF secretion in injured arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Methotrexate as a steroid sparing agent for asthma in adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Vitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Evidence of a role of tumor necrosis factor alpha in refractory asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Anti-TNF inhibits the airways neutrophilic inflammation induced by inhaled endotoxin in human

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Statin use and asthma control in patients with severe asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Statin use reduces decline in lung function: VA Normative Aging Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Long-term methotrexate treatment in corticosteroid-dependent asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

Evidence for a cross-talk between human neutrophils and Th17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17476348.2017.1268919

10.1080/17476348.2017.1268919

21 January 2018

Identifiers

DOI

1 reference

20 September 2017

1 reference