Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells. (Q40393851)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23183826%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

title

Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells (English)

1 reference

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18 February 2020

1 reference

4

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18 February 2020

Mariaelena Repici

1

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18 February 2020

Kornelis Straatman

2

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18 February 2020

Tiago Fleming Outeiro

5

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18 February 2020

author name string

Nadia Balduccio

3

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18 February 2020

Flaviano Giorgini

6

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18 February 2020

publication date

27 November 2012

1 reference

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Journal of Molecular Medicine

18 February 2020

published in

1 reference

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18 February 2020

volume

91

1 reference

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18 February 2020

issue

5

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18 February 2020

page(s)

599-611

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https://scigraph.springernature.com/pub.10.1007/s00109-012-0976-y

18 February 2020

exact match

0 references

cites work

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What genetics tells us about the causes and mechanisms of Parkinson's disease

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Recent advances in the genetics of Parkinson's disease

22 September 2017

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L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments

22 September 2017

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Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

22 September 2017

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DJ-1, PINK1, and their effects on mitochondrial pathways

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Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

22 September 2017

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Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1

22 September 2017

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22 September 2017

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Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent Manner

22 September 2017

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Molecular basis for the structural instability of human DJ-1 induced by the L166P mutation associated with Parkinson's disease

22 September 2017

1 reference

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Structural effects of Parkinson's disease linked DJ-1 mutations.

22 September 2017

1 reference

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On the oligomeric state of DJ-1 protein and its mutants associated with Parkinson Disease. A combined computational and in vitro study.

22 September 2017

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Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells

22 September 2017

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Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

22 September 2017

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Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

22 September 2017

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Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization

22 September 2017

1 reference

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

22 September 2017

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Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

22 September 2017

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Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7).

22 September 2017

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The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

22 September 2017

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A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

22 September 2017

1 reference

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Differential Effects of Parkinson's Disease-associated Mutations on Stability and Folding of DJ-1

22 September 2017

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The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3644405

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

22 September 2017

1 reference

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The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease

22 September 2017

1 reference

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Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease

22 September 2017

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Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis

22 September 2017

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Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

22 September 2017

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HotPatch: a statistical approach to finding biologically relevant features on protein surfaces

22 September 2017

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Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients

17 June 2018

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Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease

17 June 2018

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Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease

20 August 2018

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Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3644405

The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3644405

Visualization of Protein Interactions in Living Cells Using Bimolecular Fluorescence Complementation (BiFC) Analysis

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3644405

Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23183826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23183826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23183826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00109-012-0976-Y

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23183826%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23183826%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

23183826

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23183826%20AND%20SRC:MED&resulttype=core&format=json