Phase 2, randomized, double-blind study of pracinostat in combination with azacitidine in patients with untreated, higher-risk myelodysplastic syndromes (Q40377702)

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scientific article published on 17 January 2017

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English	Phase 2, randomized, double-blind study of pracinostat in combination with azacitidine in patients with untreated, higher-risk myelodysplastic syndromes	scientific article published on 17 January 2017

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24 May 2018

http://europepmc.org/abstract/PMC/5432122

Phase 2, randomized, double-blind study of pracinostat in combination with azacitidine in patients with untreated, higher-risk myelodysplastic syndromes (English)

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24 May 2018

http://europepmc.org/abstract/PMC/5432122

3-[2-butyl-1-[2-(diethylamino)ethyl]-5-benzimidazolyl]-N-hydroxy-2-propenamide

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ChEBI release 2020-05-28

Hagop Kantarjian

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Hagop M Kantarjian

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Farhad Ravandi

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Elias Jabbour

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Guillermo Garcia-Manero

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Guillermo Garcia-Manero

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Jesus G Berdeja

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Jesus G Berdeja

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Amy E DeZern

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Rami S Komrokji

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Rami S Komrokji

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Gail J Roboz

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Mikkael A Sekeres

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Mikkael A Sekeres

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Guillermo Montalban-Bravo

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Philip Kuriakose

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Philip Kuriakose

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Yasmin Abaza

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James Essell

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Roger M Lyons

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Michael Maris

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Brian Heller

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Sunil Babu

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David Wright

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Bertrand Anz

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Ralph Boccia

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James Reeves

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Richard Ghalie

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17 January 2017

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994-1002

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Clinical implications of TP53 mutations in myelodysplastic syndromes treated with hypomethylating agents

1 reference

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15 June 2018

Azacitidine with or without Entinostat for the treatment of therapy-related myeloid neoplasm: further results of the E1905 North American Leukemia Intergroup study.

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Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

1 reference

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Results of phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia

1 reference

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15 June 2018

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5432122

15 June 2018

Prognostic value of TP53 gene mutations in myelodysplastic syndromes and acute myeloid leukemia treated with azacitidine

1 reference

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15 June 2018

Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905.

1 reference

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15 June 2018

Revised international prognostic scoring system for myelodysplastic syndromes

1 reference

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15 June 2018

Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure

1 reference

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Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile

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Pharmacodynamic evaluation of the target efficacy of SB939, an oral HDAC inhibitor with selectivity for tumor tissue

1 reference

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15 June 2018

Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5432122

15 June 2018

A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5432122

15 June 2018

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5432122

15 June 2018

Epigenetic therapy in cancer: molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors

1 reference

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CpG island methylation and histone modifications: biology and clinical significance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5432122

15 June 2018

Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

1 reference

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Antileukemia activity of the combination of 5-aza-2'-deoxycytidine with valproic acid

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

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15 June 2018

DNA methylation models histone acetylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5432122

15 June 2018

International scoring system for evaluating prognosis in myelodysplastic syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5432122

15 June 2018

Randomized Phase II Study of Azacitidine Alone or in Combination With Lenalidomide or With Vorinostat in Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: North American Intergroup Study SWOG S1117.

1 reference

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20 August 2018

A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5432122

20 August 2018

TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5432122

20 August 2018

Comparison of various criteria in predicting treatment response and prognosis of patients with myelodysplastic syndrome treated with azacitidine.

1 reference

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20 August 2018

Nonparametric Estimation from Incomplete Observations

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.30533

21 January 2018

Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.30533

21 January 2018

Clinical outcome after failure of hypomethylating therapy for myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.30533

7 January 2021

based on heuristic

inferred from DOI database lookup

Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.30533

7 January 2021

based on heuristic

inferred from DOI database lookup

Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.30533

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CNCR.30533

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/PMC/5432122

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/PMC/5432122

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/PMC/5432122

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