Phase-I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer (Q40370693)

19 September 2017

Phase-I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer (English)

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19 September 2017

phase I clinical trial

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K Anwer

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M N Barnes

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J Fewell

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D H Lewis

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R D Alvarez

5

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24 December 2009

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360-369

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https://scigraph.springernature.com/pub.10.1038/gt.2009.159

19 September 2017

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Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

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IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy

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Interleukin-12-mediated tumoricidal activity of patient lymphocytes in an autologous in vitro ovarian cancer assay system

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Antitumoral effect of interleukin-12-secreting fibroblasts in a mouse model of ovarian cancer: implications for the use of ovarian cancer biopsy-derived fibroblasts as a vehicle for regional gene therapy

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Synthesis and application of a non-viral gene delivery system for immunogene therapy of cancer

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Treatment of disseminated ovarian cancer using nonviral interleukin-12 gene therapy delivered intraperitoneally

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Intraperitoneal chemotherapy as primary treatment of advanced ovarian cancer: efficacy, toxicity, and future directions

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Intraperitoneal cisplatin and paclitaxel in ovarian cancer.

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Phase II study of intraperitoneal recombinant interleukin-12 (rhIL-12) in patients with peritoneal carcinomatosis (residual disease < 1 cm) associated with ovarian cancer or primary peritoneal carcinoma

21 January 2018

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Intratumoral administration of a recombinant canarypox virus expressing interleukin 12 in patients with metastatic melanoma.

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A safety and efficacy study of local delivery of interleukin-12 transgene by PPC polymer in a model of experimental glioma.

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Percutaneous placement of peritoneal port-catheter in oncologic patients.

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

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7 January 2021

Immunoregulation by interleukin-12.

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Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responses

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Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2

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The role of CXC chemokines as regulators of angiogenesis

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Molecular mechanisms underlying IFN-gamma-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12

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Interleukin-12 requires initial CD80-mediated T-cell activation to support immune responses toward human breast and ovarian carcinoma

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7 January 2021

Effects of IL-12 on human ovarian tumors engrafted into SCID mice

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7 January 2021

Interleukin-12-gene transduction makes DCs from tumor-bearing mice an effective inducer of tumor-specific immunity in a peritoneal dissemination model

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7 January 2021

https://api.crossref.org/works/10.1038%2FGT.2009.159

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Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial

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7 January 2021

Intratumoral injection of DNA encoding human interleukin 12 into patients with metastatic melanoma: clinical efficacy

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7 January 2021

Identifiers

DOI

10.1038/GT.2009.159

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Dimensions Publication ID

19 September 2017

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