CD63 molecule (Q4035583)

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mammalian protein found in Homo sapiens

ocular melanoma-associated antigen
melanoma-associated antigen MLA1
lysosome-associated membrane glycoprotein 3
CD63 antigen (melanoma 1 antigen)
OMA81H
lysosomal-associated membrane protein 3
CD63
LAMP-3
melanoma-associated antigen ME491
granulophysin
tetraspanin-30
CD63 antigen
tspan-30
Tetraspanin 30

Language	Label	Description	Also known as
English	CD63 molecule	mammalian protein found in Homo sapiens	ocular melanoma-associated antigen melanoma-associated antigen MLA1 lysosome-associated membrane glycoprotein 3 CD63 antigen (melanoma 1 antigen) OMA81H lysosomal-associated membrane protein 3 CD63 LAMP-3 melanoma-associated antigen ME491 granulophysin tetraspanin-30 CD63 antigen tspan-30 Tetraspanin 30

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

3 references

8 April 2019

Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Investigation of membrane protein-protein interactions using correlative FRET-PLA

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

multivesicular body

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

multivesicular body membrane

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

intrinsic component of plasma membrane

determination method

2 references

8 April 2019

Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

plasma membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

integral component of plasma membrane

determination method

1 reference

17 October 2017

CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

determination method

1 reference

8 April 2019

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

lysosomal membrane

determination method

5 references

17 October 2017

CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

17 October 2017

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

17 October 2017

Integral and associated lysosomal membrane proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

17 October 2017

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

extracellular region

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

platelet dense granule membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

extracellular exosome

determination method

7 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

17 October 2017

Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

17 October 2017

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

17 October 2017

Exosomal-like vesicles are present in human blood plasma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

extracellular space

determination method

1 reference

8 April 2019

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

azurophil granule membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

lysosomal membrane

determination method

5 references

8 April 2019

CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Integral and associated lysosomal membrane proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

multivesicular body membrane

determination method

extracellular exosome

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Exosomal-like vesicles are present in human blood plasma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

biological process

positive regulation of receptor internalization

determination method

1 reference

8 April 2019

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

platelet degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

pigment granule maturation

determination method

1 reference

8 April 2019

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

endosome to melanosome transport

determination method

1 reference

8 April 2019

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

protein transport

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

positive regulation of integrin-mediated signaling pathway

determination method

2 references

8 April 2019

Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

cell-matrix adhesion

determination method

1 reference

8 April 2019

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

determination method

1 reference

8 April 2019

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08962&geneProductId=UniProtKB:P08962

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

pigment cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

regulation of vascular endothelial growth factor signaling pathway

determination method

cell surface receptor signaling pathway

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

determination method

positive regulation of endocytosis

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

regulation of potassium ion transmembrane transport

determination method

1 reference

8 April 2019

CD63 interacts with the carboxy terminus of the colonic H+-K+-ATPase to decrease [corrected] plasma membrane localization and 86Rb+ uptake

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

regulation of vascular endothelial growth factor signaling pathway

determination method

3 references

8 April 2019

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08962

determination method

Gene Atlas image

PBB GE CD63 200663 at fs.png
732 × 530; 11 KB

0 references

Tetraspanin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08962

Identifiers

MeSH descriptor ID

subject named as

Tetraspanin 30

0 references

D12.776.395.550.550.249

0 references

D12.776.543.550.527.249

0 references

D12.776.543.900.163

0 references

D12.776.543.990.024

0 references

D09.400.430.890.550.249

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000257857

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000257857

ENSP00000393502

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393502

ENSP00000446807

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446807

ENSP00000447356

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447356

ENSP00000447730

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447730

ENSP00000448091

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448091

ENSP00000449337

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449337

ENSP00000446752

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446752

ENSP00000447938

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447938

ENSP00000449281

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449281

ENSP00000449435

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449435

ENSP00000449654

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449654

ENSP00000449684

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449684

ENSP00000450191

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450191

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(7 entries)

dewiki CD63
enwiki CD63
fawiki CD63
ruwiki CD63
ttwiki CD63
ukwiki CD63
zhwiki CD63

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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