Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport. (Q40334719)

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15 January 2020

title

Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport (English)

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8

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author name string

Toshiyuki Sakaeda

1

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15 January 2020

Hideki Fujino

2

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15 January 2020

Chiho Komoto

3

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15 January 2020

Mikio Kakumoto

4

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15 January 2020

Jiang-Shu Jin

5

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15 January 2020

Koichi Iwaki

6

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15 January 2020

Kohshi Nishiguchi

7

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15 January 2020

Noboru Okamura

9

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15 January 2020

Katsuhiko Okumura

10

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publication date

1 January 2006

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15 January 2020

published in

Pharmaceutical Research

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volume

23

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issue

3

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page(s)

506-512

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Potential Role of Statins in Inflammation and Atherosclerosis

15 January 2020

cites work

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Cholesterol-independent effects of statins and new therapeutic targets: ischemic stroke and dementia

21 January 2018

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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

21 January 2018

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Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin

21 January 2018

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21 January 2018

12 December 2020

Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs

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12 December 2020

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

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12 December 2020

Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance.

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12 December 2020

Gemfibrozil greatly increases plasma concentrations of cerivastatin

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12 December 2020

Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors

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12 December 2020

Simultaneous determination of taxol and its metabolites in microsomal samples by a simple thin-layer chromatography radioactivity assay--inhibitory effect of NK-104, a new inhibitor of HMG-CoA reductase

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12 December 2020

Simvastatin and lovastatin, but not pravastatin, interact with MDR1.

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12 December 2020

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

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12 December 2020

Pharmacogenetics of drug transporters and its impact on the pharmacotherapy.

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12 December 2020

Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization

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12 December 2020

Atomic physicochemical parameters for three-dimensional-structure-directed quantitative structure-activity relationships. 2. Modeling dispersive and hydrophobic interactions

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12 December 2020

Oral anticoagulant drug interactions with statins: case report of fluvastatin and review of the literature

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12 December 2020

Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes

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12 December 2020

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

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12 December 2020

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells

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12 December 2020

The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

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12 December 2020

Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance

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12 December 2020

Role of P-glycoprotein in pharmacokinetics: clinical implications

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12 December 2020

Efficacy and drug interactions of the new HMG-CoA reductase inhibitors cerivastatin and atorvastatin in CsA-treated renal transplant recipients

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12 December 2020

Effect of itraconazole on the pharmacokinetics of atorvastatin

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12 December 2020

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

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12 December 2020

Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors

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12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Beyond lipid-lowering: effects of statins on endothelial nitric oxide

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12 December 2020

The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective

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12 December 2020

Metabolic fate of pitavastatin (NK-104), a new inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase. Effects on drug-metabolizing systems in rats and humans

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12 December 2020

The effect of rosuvastatin on oestrogen & progestin pharmacokinetics in healthy women taking an oral contraceptive

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12 December 2020

Atorvastatin does not alter the anticoagulant activity of warfarin

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12 December 2020

Rosuvastatin-warfarin drug interaction

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12 December 2020

Active secretion and enterocytic drug metabolism barriers to drug absorption

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12 December 2020

Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein

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12 December 2020

Clinical significance of the atorvastatin-clopidogrel drug-drug interaction

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12 December 2020

Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin

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12 December 2020

Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: similarities and difference in the metabolism of pitavastatin in monkeys and humans

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12 December 2020

A convenient assay for mephenytoin 4-hydroxylase activity of human liver microsomal cytochrome P-450.

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12 December 2020

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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12 December 2020

Digoxin-cyclosporin A interaction: modulation of the multidrug transporter P-glycoprotein in the kidney

1 reference

12 December 2020

Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization

1 reference

12 December 2020

Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.

1 reference

12 December 2020

Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin

1 reference

12 December 2020

Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney.

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12 December 2020

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone

1 reference

12 December 2020

Assessment of microsomal tolbutamide hydroxylation by a simple thin-layer chromatography radioactivity assay

1 reference

12 December 2020

10.1007/S11095-005-9371-5

Identifiers

DOI

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15 January 2020

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